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Substance Name: Debrisoquine [INN:BAN]
RN: 1131-64-2
UNII: X31CDK040E
InChIKey: JWPGJSVJDAJRLW-UHFFFAOYSA-N

Note

  • An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.

Molecular Formula

  • C10-H13-N3

Molecular Weight

  • 175.234
 

Classification Codes

  • Adrenergic Agents
  • Antihypertensive Agents
  • Autonomic Agents
  • Cardiovascular Agents
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Sympatholytics
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Names and Synonyms

Name of Substance

  • Debrisoquin
  • Debrisoquine [INN:BAN]

MeSH Heading

  • Debrisoquin

Synonyms

  • Debrisochinum
  • Debrisoquin
  • Debrisoquina
  • Debrisoquina [INN-Spanish]
  • Debrisoquine
  • Debrisoquinum
  • Debrisoquinum [INN-Latin]
  • EINECS 214-470-1
  • Tendor
  • UNII-X31CDK040E

Systematic Names

  • 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-
  • Debrisoquine

Registry Numbers

CAS Registry Number

  • 1131-64-2

FDA UNII

  • X31CDK040E

System Generated Number

  • 0001131642

Structure Descriptors

InChI

1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12)

InChIKey

JWPGJSVJDAJRLW-UHFFFAOYSA-N

Smiles

c12c(CCN(C1)C(N)=N)cccc2

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 278-280 deg C   EXP
log P (octanol-water) 0.75 (none)   EXP
Water Solubility 1.33E+04 mg/L 25 EST
Vapor Pressure 1.33E-04 mm Hg 25 EST
Henry's Law Constant 4.43E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.13E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.