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Substance Name: Onartuzumab [USAN:INN]
RN: 1133766-06-9
UNII: MS1J9720WC

Note

  • NCI: A humanized monovalent monoclonal antibody directed against the hepatocyte growth factor receptor (c-Met) with potential antineoplastic activity. Anti-MET monoclonal antibody MetMAb binds to the extracellular domain of c-Met, preventing the binding of its ligand, hepatocyte growth factor (HGF); the activation of the c-Met signaling pathway is thus inhibited, which may result in cell death in c-Met-expressing tumor cells. c-Met, a receptor tyrosine kinase, is overexpressed on the cell surfaces of a variety of cancer cell types and may play a key role in their proliferation, invasion and survival. (NCI Thesaurus)
 

Classification Code

  • Treatment of Cancer
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Links to Resources

Names and Synonyms

Name of Substance

  • Onartuzumab [USAN:INN]

Synonyms

  • MetMAb
  • Onartuzumab
  • PRO143966
  • UNII-MS1J9720WC

Systematic Name

  • Immunoglobulin G1, anti-(human scatter factor receptor kinase)(human-mouse monoclonal MetMAb heavy chain), disulfide with human-mouse monoclonal MetMAb kappa-chain, disulfide with human-mouse monoclonal MetMAb heavy chain hinge region-CH2-CH3 domain-containing fragment

Registry Numbers

CAS Registry Number

  • 1133766-06-9

FDA UNII

  • MS1J9720WC

System Generated Number

  • 1133766069