Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Cidofovir [INN]
RN: 113852-37-2
UNII: 768M1V522C
InChIKey: VWFCHDSQECPREK-LURJTMIESA-N

Note

  • NLM: Potent, selective inhibitor of human cytomegalovirus replication; used for treat ment of CMV retinitis.

    NCI: A synthetic, acyclic, monophosphate nucleotide analog of deoxycytidine with antiviral activity, and mostly used against cytomegalovirus (CMV). After incorporation into the host cell, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated into the growing viral DNA strands. As a result, it prevents further DNA polymerization and disrupts DNA replication of viruses. (NCI Thesaurus)

Molecular Formula

  • C8-H14-N3-O6-P

Molecular Weight

  • 279.188
 

Classification Codes

  • Anti-HIV Agents
  • Anti-Infective Agents
  • Anti-Retroviral Agents
  • Antineoplastic Agents
  • Antiviral
  • Antiviral Agents
  • Radiation-Sensitizing Agents
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Results Name

  • Cidofovir [INN]

Name of Substance

  • Cidofovir
  • Cidofovir (anhydrous)
  • Cidofovir [INN]

Synonyms

  • (S)-1-(3-Hydroxy-2-phosphonomethoxypropyl)cytosine
  • (S)-HPMPC
  • Cidofovir
  • GS 0504
  • HPMPC
  • HSDB 7115
  • UNII-768M1V522C
  • Vistide

Systematic Name

  • Phosphonic acid, ((2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy)methyl)-, (S)-

Superlist Name

  • Cidofovir

Registry Numbers

CAS Registry Number

  • 113852-37-2

FDA UNII

  • 768M1V522C

Related Registry Number

  • 120362-37-0 (hydrochloride salt)

System Generated Number

  • 0113852372

Structure Descriptors

InChI

1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1

InChIKey

VWFCHDSQECPREK-LURJTMIESA-N

Smiles

n1(C[C@H](OCP(O)(O)=O)CO)c(nc(N)cc1)=O