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Substance Name: Neostigmine bromide [USP:INN:BAN:JAN]
RN: 114-80-7
UNII: 005SYP50G5
InChIKey: LULNWZDBKTWDGK-UHFFFAOYSA-M

Classification Codes

  • Cholinergic
  • Drug / Therapeutic Agent

Molecular Formula

  • C12-H19-N2-O2.Br

Molecular Weight

  • 303.1981
 
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Names and Synonyms

Name of Substance

  • Neostigmine bromide [USP:INN:BAN:JAN]

Synonyms

  • (m-Hydroxyphenyl)trimethylammonium bromide dimethylcarbamate
  • 3-Dimethylcarbamoxyphenyl trimethyl ammonium bromide
  • 3-Hydroxyphenyltrimethylammonium bromide dimethylcarbamic ester
  • Benzenaminium, 3-(((dimethylamino)carbonyl)oxy)-N,N,N-trimethyl-, bromide
  • Bromure de neostigmine
  • Bromure de neostigmine [INN-French]
  • Bromuro de neostigmina
  • Bromuro de neostigmina [INN-Spanish]
  • Carbamic acid, dimethyl-, ester with (m-hydroxyphenyl)trimethylammonium bromide
  • EINECS 204-054-8
  • Eustigmin bromide
  • Kirkstigmine bromide
  • Leostigmine bromide
  • neo-Proserin
  • Neoserine bromide
  • Neostigmina bromuro
  • Neostigmina bromuro [DCIT]
  • Neostigmine bromide
  • Neostigmine methyl bromide
  • Neostigmini bromidum
  • Neostigmini bromidum [INN-Latin]
  • Philostigmin bromide
  • Proserine bromide
  • Prostigmin bromide
  • Prostigmine bromide
  • RCRA waste number U053
  • Stigmanol bromide
  • Stigmosan bromide
  • Synstigmin bromide
  • Synstigminbromid
  • Synstigmini bromidum
  • Synthostigmine bromide
  • Syntostigmin (tablet)
  • Syntostigmin bromide
  • Syntostigmine bromide
  • UNII-005SYP50G5
  • Vagostigmine bromide

Systematic Names

  • Ammonium, (m-hydroxyphenyl)trimethyl-, bromide, dimethylcarbamate
  • Benzenaminium, 3-(((dimethylamino)carbonyl)oxy)-N,N,N-trimethyl-, bromide
  • Neostigmine bromide

Registry Numbers

CAS Registry Number

  • 114-80-7

FDA UNII

  • 005SYP50G5

Related Registry Number

  • 59-99-4 (Parent)

System Generated Number

  • 0000114807

Molecular Formulas

Molecular Formula

  • C12-H19-N2-O2.Br

Molecular Formula Fragments

  • Br
  • C12-H19-N2-O2
  • COMPONENT

Structure Descriptors

InChI

1S/C12H19N2O2.BrH/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;/h6-9H,1-5H3;1H/q+1;/p-1

InChIKey

LULNWZDBKTWDGK-UHFFFAOYSA-M

Smiles

CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C.[Br-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 171ug/kg (0.171mg/kg)   Drugs in Japan Vol. 6, Pg. 352, 1982.
cat LD50 oral 7449ug/kg (7.449mg/kg)   Drugs in Japan Vol. 6, Pg. 352, 1982.
mouse LD50 intraperitoneal 610ug/kg (0.61mg/kg)   Journal of Pharmaceutical Sciences. Vol. 57, Pg. 172, 1968.
mouse LD50 intravenous 130ug/kg (0.13mg/kg)   Pharmaceutical Chemistry Journal Vol. 16, Pg. 164, 1982.
mouse LD50 oral 7mg/kg (7mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 120, Pg. 511, 1965.
mouse LD50 subcutaneous 420ug/kg (0.42mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 16, 1950.
mouse LD50 unreported 380ug/kg (0.38mg/kg)   Pharmaceutical Chemistry Journal Vol. 3, Pg. 508, 1969.
rat LD50 intravenous 165ug/kg (0.165mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 701, 1950.
rat LD50 oral 51mg/kg (51mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 120, Pg. 511, 1965.
rat LD50 subcutaneous 370ug/kg (0.37mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 701, 1950.
rat LDLo intraperitoneal 835ug/kg (0.835mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 136, Pg. 20, 1962.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Water Solubility 5.00E+05 mg/L   EXP

Physical property data is provided to ChemIDplus by SRC, Inc.