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Substance Name: Bethanidine sulfate [USAN]
RN: 114-85-2
UNII: J4THI5N7O2
InChIKey: YTIJUXVIZLYQTB-UHFFFAOYSA-N

Note

  • A guanidinium antihypertensive agent that acts by blocking adrenergic transmission. The precise mode of action is not clear.

Molecular Formula

  • C10-H15-N3.1/2H2-O4-S

Molecular Weight

  • 452.5768
 

Classification Codes

  • Antihypertensive
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Bethanidine sulfate
  • Bethanidine sulfate [USAN]
  • Regulin

Synonyms

  • 1-Benzyl-2,3-dimethylguanidine sulfate (1:(12))
  • 1-Benzyl-2,3-dimethylguanidine sulfate (1:1/2)
  • 1-Benzyl-2,3-dimethylguanidinium sulfate
  • Batel
  • Bendogen
  • Bentanidol
  • Benzaidin
  • Benzanidin
  • Benzanidine
  • Benzoxine
  • Betaling
  • Betanidine sulfate
  • Bethanidine sulfate
  • Bethanidine, hemisulfate
  • BW 467 C-60
  • BW-467-C-60
  • EINECS 204-056-9
  • Esbatal
  • Eusmanid
  • Guanidine, N,N'-dimethyl-N''-(phenylmethyl)-, sulfate (2:1)
  • Guanidine, N,N'-dimethyl-N'-(phenylmethyl)-, sulfate (2:1)
  • Hypersin
  • N,N-Dimethyl''-(phenylmethyl)guanidine sulphate (2:1)
  • N-Benzyl-N',N''-dimethylguanidine sulfate
  • N-Benzyl-N',N''-dimethylguanidine sulphate
  • NSC-106563
  • Regulin
  • Tenathan
  • UNII-J4THI5N7O2

Systematic Names

  • 1-Benzyl-2,3-dimethylguanidinium sulphate (2:1)
  • Guanidine, 1-benzyl-2,3-dimethyl-, sulfate(2:1)
  • Guanidine, N,N'-dimethyl-N''-(phenylmethyl)-, sulfate (2:1)

Registry Numbers

CAS Registry Number

  • 114-85-2

FDA UNII

  • J4THI5N7O2

Related Registry Number

  • 55-73-2 (Parent)

System Generated Number

  • 0000114852

Molecular Formulas

Molecular Formula

  • C10-H15-N3.1/2H2-O4-S

Molecular Formula Fragments

  • C10-H15-N3
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/2C10H15N3.H2O4S/c2*1-11-10(12-2)13-8-9-6-4-3-5-7-9;1-5(2,3)4/h2*3-7H,8H2,1-2H3,(H2,11,12,13);(H2,1,2,3,4)

InChIKey

YTIJUXVIZLYQTB-UHFFFAOYSA-N

Smiles

C[NH2+]\C(=N\C)\NCc1ccccc1.C[NH2+]\C(=N\C)\NCc2ccccc2.[O-]S(=O)(=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LDLo intravenous 100mg/kg (100mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 20, Pg. 36, 1963.
mouse LD50 intraperitoneal 150mg/kg (150mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 20, Pg. 36, 1963.
mouse LD50 intravenous 12mg/kg (12mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 20, Pg. 36, 1963.
mouse LD50 oral 520mg/kg (520mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 20, Pg. 36, 1963.
mouse LD50 subcutaneous 260mg/kg (260mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 20, Pg. 36, 1963.
rat LD50 intravenous 20mg/kg (20mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 72, Pg. 837, 1976.