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Substance Name: Cabozantinib s-malate [USAN]
RN: 1140909-48-3
UNII: DR7ST46X58
InChIKey: HFCFMRYTXDINDK-WNQIDUERSA-N

Note

  • A multikinase inhibitor.

    NCI: The s-malate salt form of cabozantinib, an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several RTKs, which are often overexpressed in a variety of cancer cell types, including hepatocyte growth factor receptor (MET), RET (rearranged during transfection), vascular endothelial growth factor receptor types 1 (VEGFR-1), 2 (VEGFR-2), and 3 (VEGFR-3), mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (FLT-3), TIE-2 (TEK tyrosine kinase, endothelial), tropomyosin-related kinase B (TRKB) and AXL. This may result in an inhibition of both tumor growth and angiogenesis, and eventually lead to tumor regression. (NCI Thesaurus)

Molecular Formula

  • C28-H24-F-N3-O5.C4-H6-O5

Molecular Weight

  • 635.598
 

Classification Code

  • Antineoplastic
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Names and Synonyms

Name of Substance

  • Cabozantinib s-malate [USAN]

Synonyms

  • BMS 907351
  • BMS907351
  • Cabometyx
  • Cabozantinib (s)-malate
  • Cabozantinib malate
  • Cabozantinib s-malate
  • Cometriq
  • UNII-DR7ST46X58
  • XL 184
  • XL-184
  • XL184

Systematic Name

  • 1,1-Cyclopropanedicarboxamide, N'-(4-((6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4- fluorophenyl)- mono((2S)-2-hydroxybutanedioate)

Registry Numbers

CAS Registry Number

  • 1140909-48-3

FDA UNII

  • DR7ST46X58

Other Registry Number

  • 942407-59-2

System Generated Number

  • 1140909483

Structure Descriptors

InChI

1S/C28H24FN3O5.C4H6O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18;5-2(4(8)9)1-3(6)7/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34);2,5H,1H2,(H,6,7)(H,8,9)/t;2-/m.0/s1

InChIKey

HFCFMRYTXDINDK-WNQIDUERSA-N