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Substance Name: Tabalumab [USAN:INN]
RN: 1143503-67-6


  • Anti-B-cell activating factor (BAFF) human monoclonal antibody.
  • NCI: A human IgG4 monoclonal antibody against B-cell activating factor (BAFF), with potential immunomodulating and antineoplastic activities. Tabalumab binds to and inhibits the activity of both soluble and cell surface-bound BAFF. This may reduce the activity, proliferation and survival of B-cells. A dysregulated expression of BAFF, a member of the tumor necrosis factor (TNF) family of proteins, is often seen in certain autoimmune diseases and certain cancers, and may promote B lymphocyte activation, proliferation and survival. (NCI Thesaurus)

Molecular Formula

  • C6518-H10008-N1724-O2032-S38

Classification Code

  • Autoimmune Diseases and B Cell Malignancies
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Links to Resources

Names and Synonyms

Name of Substance

  • Tabalumab [USAN:INN]


  • LY 2127399
  • LY-2127399
  • LY2127399
  • Tabalumab

Systematic Name

  • Immunoglobulin G4, anti-(human cytokine BAFF) (human monoclonal LY2127399 gamma4- chain), disulfide with human monoclonal LY2127399 kappa-chain, dimer

Registry Numbers

CAS Registry Number

  • 1143503-67-6



System Generated Number

  • 1143503676