Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: 6-((Piperidino)acetoxy)-7-desacetylforskolin
RN: 114376-11-3
InChIKey: QGRXRBJNZDDDHY-YHEOSNBFSA-N

Note

  • Activates adenylate cyclase.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C27-H43-N-O7.Cl-H.H2-O

Molecular Weight

  • 530.098
 
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Other Resources (Internet Locators)


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • 6-((Piperidino)acetoxy)-7-desacetylforskolin

Synonyms

  • 8,13-Epoxy-6-beta-(piperidinoacetoxy)-1-alpha,7-beta,9-alpha-trihydroxy-labd-14-en-11-one HCl
  • HL 706

Systematic Name

  • 1-Piperidineacetic acid, 3-ethenyldodecahydro-1-oxo-3,4a,7,7,10a-pentamethyl-5,10,10b-trihydroxy-1H-naphtho(2,1-b)pyran-6-yl ester, hydrochloride, hydrate, (3R-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,10-alpha,10a-beta,10b-alpha))-

Registry Numbers

CAS Registry Number

  • 114376-11-3

System Generated Number

  • 0114376113

Molecular Formulas

Molecular Formula

  • C27-H43-N-O7.Cl-H.H2-O

Molecular Formula Fragments

  • C27-H43-N-O7
  • Cl-H
  • COMPONENT
  • H2-O

Structure Descriptors

InChI

1S/C27H43NO7.ClH/c1-7-24(4)15-18(30)27(33)25(5)17(29)11-12-23(2,3)21(25)20(22(32)26(27,6)35-24)34-19(31)16-28-13-9-8-10-14-28;/h7,17,20-22,29,32-33H,1,8-16H2,2-6H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1

InChIKey

QGRXRBJNZDDDHY-YHEOSNBFSA-N

Smiles

C1[C@@H]([C@@]2([C@@]3([C@]([C@H]([C@H]([C@H]2C(C1)(C)C)OC(=O)CN1CCCCC1)O)(C)O[C@@](CC3=O)(C)C=C)O)C)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 85mg/kg (85mg/kg)   Journal of Medicinal Chemistry. Vol. 31, Pg. 1872, 1988.
mouse LD50 intravenous 73mg/kg (73mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 43, Pg. 313, 1993.
mouse LD50 oral 230mg/kg (230mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 43, Pg. 313, 1993.