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Substance Name: Aroplatin
RN: 114488-24-3
InChIKey: ALPHSAWEOKVWID-UHFFFAOYSA-L

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C26-H52-N2-O4-Pt

Molecular Weight

  • 649.771
 
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Names and Synonyms

Results Name

  • Aroplatin

Name of Substance

  • Bis-neodecanoato-1,2-diaminocyclohexaneplatinum(II)

Synonyms

  • (1,2-Cyclohexanediamine-N,N')bis(neodecanoato-O)platinum
  • Aroplatin
  • cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum(II)
  • L-NDDP
  • NDDP
  • Neodecanoic acid, platinum complex
  • Platinum, bis(neodecanoato)(trans-1,2-cyclohexanediammine)-, (Z)-

Systematic Names

  • Platinum, (1,2-cyclohexanediamine-kappaN,kappaN')bis(neodecanoato)-kappaO)-
  • Platinum, (1,2-cyclohexanediamine-N,N')bis(neodecanoato-O)-

Registry Numbers

CAS Registry Number

  • 114488-24-3

Other Registry Numbers

  • 109488-20-2
  • 209052-65-3

System Generated Number

  • 0114488243

Structure Descriptors

InChI

1S/2C10H20O2.C6H12N2.Pt/c2*1-10(2,3)8-6-4-5-7-9(11)12;7-5-3-1-2-4-6(5)8;/h2*4-8H2,1-3H3,(H,11,12);5-8H,1-4H2;/q;;-2;+4/p-2

InChIKey

ALPHSAWEOKVWID-UHFFFAOYSA-L

Smiles

CC(C)(C)CCCCCC(=O)[O-][Pt+2]1(NC2CCCCC2N1)[O-]C(=O)CCCCCC(C)(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 225mg/kg (225mg/kg) BLOOD: HEMORRHAGE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Cancer Chemotherapy and Pharmacology. Vol. 24, Pg. 1, 1989.
mouse LD50 intravenous 60500ug/kg (60.5mg/kg) KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"

BLOOD: GRANULOCYTOPENIA
Cancer Chemotherapy and Pharmacology. Vol. 24, Pg. 1, 1989.