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Substance Name: Acitazanolast [INN]
RN: 114607-46-4
UNII: 99Y8VJ356G
InChIKey: VWQZJJZGISNFOE-UHFFFAOYSA-N

Note

  • A leukotriene D4 antagonist.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C9-H7-N5-O3

Molecular Weight

  • 233.186
 
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Names and Synonyms

Name of Substance

  • Acitazanolast
  • Acitazanolast [INN]

Synonyms

  • 3'-(1H-Tetrazol-5-yl)oxanilic acid monohydrate
  • Acitazanolast
  • CCRIS 7505
  • MTCC
  • N-(3-(1H-Tetrazol-5-yl)phenyl)oxamic acid
  • Oxanilic acid, 3-(1H-tetrazol-5-yl)-
  • Oxo-((3-(1H-tetrazol-5-yl)phenyl)amino)acetic acid
  • UNII-99Y8VJ356G
  • WP 871

Systematic Names

  • 3'-(1H-Tetrazol-5-yl)oxanilic acid
  • 3'-(1H-Tetrazol-5-yl)oxanilic acid monohydrate
  • Acetic acid, oxo-((3-(1H-tetrazol-5-yl)phenyl)amino)-

Registry Numbers

CAS Registry Number

  • 114607-46-4

FDA UNII

  • 99Y8VJ356G

System Generated Number

  • 0114607464

Structure Descriptors

InChI

1S/C9H7N5O3/c15-8(9(16)17)10-6-3-1-2-5(4-6)7-11-13-14-12-7/h1-4H,(H,10,15)(H,16,17)(H,11,12,13,14)

InChIKey

VWQZJJZGISNFOE-UHFFFAOYSA-N

Smiles

[nH]1c(c2cccc(NC(=O)C(=O)O)c2)nnn1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD intravenous > 1500mg/kg (1500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: NAUSEA OR VOMITING

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
Oyo Yakuri. Pharmacometrics. Vol. 49, Pg. 231, 1995.
rat LD50 intraperitoneal 1927mg/kg (1927mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BLOOD: NORMOCYTIC ANEMIA
Oyo Yakuri. Pharmacometrics. Vol. 49, Pg. 111, 1995.
rat LD50 oral > 4gm/kg (4000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 49, Pg. 111, 1995.