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Substance Name: Losartan [INN:BAN]
RN: 114798-26-4
UNII: JMS50MPO89
InChIKey: PSIFNNKUMBGKDQ-UHFFFAOYSA-N

Note

  • An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.

Molecular Formula

  • C22-H23-Cl-N6-O

Molecular Weight

  • 422.9177
 

Classification Codes

  • Angiotensin II Type 1 Receptor Blockers
  • Angiotensin Receptor Antagonists
  • Anti-Arrhythmia Agents
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Human Data

Names and Synonyms

Name of Substance

  • Losartan
  • Losartan [INN:BAN]

MeSH Heading

  • Losartan

Synonyms

  • 2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol
  • DUP 89
  • EC 601-329-8
  • HSDB 7043
  • Losartan
  • UNII-JMS50MPO89

Systematic Names

  • (1-((2'-(2H-Tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol
  • 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'- biphenyl)-4-yl)methyl)-

Mixture Name

  • Hyzaar

Registry Numbers

CAS Registry Number

  • 114798-26-4

FDA UNII

  • JMS50MPO89

Related Registry Number

  • 124750-99-8 (mono-potassium salt)

System Generated Number

  • 0114798264

Structure Descriptors

InChI

1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)

InChIKey

PSIFNNKUMBGKDQ-UHFFFAOYSA-N

Smiles

CCCCc1nc(c(n1Cc2ccc(cc2)c3ccccc3c4[nH]nnn4)CO)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 7mg/kg/1W-I (7mg/kg) LUNGS, THORAX, OR RESPIRATION: COUGH

GASTROINTESTINAL: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE
Annals of Internal Medicine. Vol. 129, Pg. 72, 1998.
man TDLo oral 17500ug/kg/17 (17.5mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE Lancet. Vol. 347, Pg. 471, 1996.
man TDLo oral 18mg/kg/13W-I (18mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE Annals of Internal Medicine. Vol. 129, Pg. 72, 1998.
man TDLo oral 21429ug/kg/30 (21.429mg/kg) LIVER: OTHER CHANGES

LIVER: LIVER FUNCTION TESTS IMPAIRED
JAMA, Journal of the American Medical Association. Vol. 278, Pg. 1572, 1997.
women TDLo oral 42mg/kg/6W-I (42mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Annals of Internal Medicine. Vol. 124, Pg. 775, 1996.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 184 deg C   EXP
pKa Dissociation Constant 5.5 (none)   EXP
log P (octanol-water) 4.010 (none)   EST
Atmospheric OH Rate Constant 5.09E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.