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Substance Name: Tezacaftor [USAN]
RN: 1152311-62-0
UNII: 8RW88Y506K
InChIKey: MJUVRTYWUMPBTR-MRXNPFEDSA-N

Classification Code

  • Treatment of Cystic Fibrosis

Molecular Formula

  • C26-H27-F3-N2-O6

Molecular Weight

  • 520.5013
 
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Names and Synonyms

Name of Substance

  • Tezacaftor [USAN]

Synonyms

  • 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-(1-((2R)-2,3-dihydroxypropyl)-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl)cyclopropanecarboxamide
  • Tezacaftor
  • UNII-8RW88Y506K
  • VX 661
  • VX-661

Systematic Name

  • Cyclopropanecarboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-(1-((2R)-2,3-dihydroxypropyl)-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl)-

Registry Numbers

CAS Registry Number

  • 1152311-62-0

FDA UNII

  • 8RW88Y506K

System Generated Number

  • 1152311620

Structure Descriptors

InChI

1S/C26H27F3N2O6/c1-24(2,13-33)22-8-14-7-18(17(27)10-19(14)31(22)11-16(34)12-32)30-23(35)25(5-6-25)15-3-4-20-21(9-15)37-26(28,29)36-20/h3-4,7-10,16,32-34H,5-6,11-13H2,1-2H3,(H,30,35)/t16-/m1/s1

InChIKey

MJUVRTYWUMPBTR-MRXNPFEDSA-N

Smiles

CC(C)(CO)c1cc2cc(c(cc2n1C[C@H](CO)O)F)NC(=O)C3(CC3)c4ccc5c(c4)OC(O5)(F)F