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Substance Name: Sdz 62-434
RN: 115621-95-9
InChIKey: BKOQATFPPHQOQH-UHFFFAOYSA-N

Note

  • May be an inhibitor of signal transduction in cancer cells; PAF antagonist.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C23-H25-N3.2Cl-H

Molecular Weight

  • 402.366
 
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Names and Synonyms

Name of Substance

  • SDZ 62-434

Synonyms

  • 2,3-Dihydro-5-(4-(1-piperidinylmethyl)phenyl)imidazo(2,1-a)isoquinoline dihydrochloride
  • 5-(4'-Piperidinomethylphenyl)-2,3-dihydroimidazo(2,1-a)isochinolin-dihydrochlorid
  • 5-(4'-Piperidinomethylphenyl)-2,3-dihydroimidazo(2,1-a)isochinolin-dihydrochlorid [German]
  • SDZ 62-434

Systematic Names

  • Imidazo(2,1-a)isoquinoline, 2,3,-dihydro-5-(4-(1-piperidinyl)phenyl)-, dihydrochloride
  • Imidazo(2,1-a)isoquinoline, 2,3-dihydro-5-(4-(1-piperidinylmethyl)phenyl)-, dihydrochloride

Registry Numbers

CAS Registry Number

  • 115621-95-9

System Generated Number

  • 0115621959

Molecular Formulas

Molecular Formula

  • C23-H25-N3.2Cl-H

Molecular Formula Fragments

  • C23-H25-N3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C22H23N3.2ClH/c1-4-13-24(14-5-1)19-10-8-17(9-11-19)21-16-18-6-2-3-7-20(18)22-23-12-15-25(21)22;;/h2-3,6-11,16H,1,4-5,12-15H2;2*1H

InChIKey

BKOQATFPPHQOQH-UHFFFAOYSA-N

Smiles

C=12c3ccccc3C=C(N2CCN1)c1ccc(cc1)N1CCCCC1.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 16mg/kg (16mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 45, Pg. 1133, 1995.
mouse LD50 oral > 300mg/kg (300mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 45, Pg. 1133, 1995.
rat LDLo oral 200mg/kg (200mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 45, Pg. 1133, 1995.