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Substance Name: Dolasetron mesylate [USAN:USP]
RN: 115956-13-3
UNII: 71YF100S3H
InChIKey: PSGRLCOSIXJUAL-ZRYPDSODSA-N

Classification Codes

  • Anti-Emetic
  • Antimigraine
  • Drug / Therapeutic Agent
  • Human Data

Molecular Formula

  • C19-H20-N2-O3.C-H4-O3-S

Molecular Weight

  • 420.4836
 

Names and Synonyms

Name of Substance

  • Dolasetron mesylate
  • Dolasetron mesylate [USAN:USP]

Synonyms

  • Anzemet
  • Dolasetron mesylate
  • Indole-3-carboxylic acid, ester with (8R)-hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one, monomethanesulfonate
  • MDL 73,147EF
  • MDL 73147EF
  • UNII-71YF100S3H

Systematic Name

  • 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2alpha,6alpha,8alpha,9abeta)-, monomethanesulfonate

Registry Numbers

CAS Registry Number

  • 115956-13-3

FDA UNII

  • 71YF100S3H

System Generated Number

  • 0115956133

Molecular Formulas

Molecular Formula

  • C19-H20-N2-O3.C-H4-O3-S

Molecular Formula Fragments

  • C-H4-O3-S
  • C19-H20-N2-O3
  • COMPONENT

Structure Descriptors

InChI

1S/C19H20N2O3.CH4O3S/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17;1-5(2,3)4/h1-4,9,11-14,20H,5-8,10H2;1H3,(H,2,3,4)/t11-,12-,13+,14+;

InChIKey

PSGRLCOSIXJUAL-ZRYPDSODSA-N

Smiles

CS(=O)(=O)O.O=C(O[C@@H]1C[C@@H]2C[C@H]3C[C@H](C1)N2CC3=O)c4c[nH]c5ccccc45

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 165mg/kg (165mg/kg)   Drugs of the Future. Vol. 18, Pg. 506, 1993.
mouse LD50 oral 545mg/kg (545mg/kg)   Drugs of the Future. Vol. 18, Pg. 506, 1993.
women TDLo intravenous 2400ug/kg/10M (2.4mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: HEADACHE
Biopharmaceutics & Drug Disposition. Vol. 18, Pg. 361, 1997.
women TDLo oral 2400ug/kg (2.4mg/kg) BEHAVIORAL: HEADACHE

GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION

GASTROINTESTINAL: OTHER CHANGES
Biopharmaceutics & Drug Disposition. Vol. 18, Pg. 361, 1997.