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Substance Name: Tosufloxacin tosilate [JAN]
RN: 115964-29-9
UNII: NO6NM634EH
InChIKey: CSSQVOKOWWIUCX-UHFFFAOYSA-N

Note

  • Quinolone anti-infective agent.

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C19-H15-F3-N4-O3.C7-H8-O3-S

Molecular Weight

  • 576.5497
 
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Names and Synonyms

Name of Substance

  • Tosufloxacin tosilate [JAN]

Synonyms

  • A 64730
  • Ozex
  • T 3262
  • Tosufloxacin tosilate
  • Tosufloxacin tosylate
  • Tosuxacin
  • UNII-NO6NM634EH

Systematic Names

  • 1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, 4-methylbenzenesulfonate (1:1)
  • 1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, mono(4-methylbenzenesulfonate)

Registry Numbers

CAS Registry Number

  • 115964-29-9

FDA UNII

  • NO6NM634EH

Other Registry Number

  • 144742-63-2

System Generated Number

  • 0115964299

Molecular Formulas

Molecular Formula

  • C19-H15-F3-N4-O3.C7-H8-O3-S

Molecular Formula Fragments

  • C19-H15-F3-N4-O3
  • C7-H8-O3-S
  • COMPONENT

Structure Descriptors

InChI

1S/C19H15F3N4O3.C7H8O3S/c20-9-1-2-15(13(21)5-9)26-8-12(19(28)29)16(27)11-6-14(22)18(24-17(11)26)25-4-3-10(23)7-25;1-6-2-4-7(5-3-6)11(8,9)10/h1-2,5-6,8,10H,3-4,7,23H2,(H,28,29);2-5H,1H3,(H,8,9,10)

InChIKey

CSSQVOKOWWIUCX-UHFFFAOYSA-N

Smiles

Cc1ccc(cc1)S(=O)(=O)O.c1cc(c(cc1F)F)n2cc(c(=O)c3c2nc(c(c3)F)N4CCC(C4)N)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 3gm/kg (3000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Chemotherapy Vol. 36(Suppl,
mouse LD50 intraperitoneal > 6gm/kg (6000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Chemotherapy Vol. 36(Suppl,
mouse LD50 intravenous 196mg/kg (196mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Chemotherapy Vol. 36(Suppl,
mouse LD50 oral > 6gm/kg (6000mg/kg)   Chemotherapy Vol. 36(Suppl,
mouse LD50 subcutaneous > 6gm/kg (6000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Chemotherapy Vol. 36(Suppl,
rat LD50 intraperitoneal > 6gm/kg (6000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Chemotherapy Vol. 36(Suppl,
rat LD50 intravenous 270mg/kg (270mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Chemotherapy Vol. 36(Suppl,
rat LD50 oral > 6gm/kg (6000mg/kg)   Chemotherapy Vol. 36(Suppl,
rat LD50 subcutaneous > 6gm/kg (6000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Chemotherapy Vol. 36(Suppl,