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Substance Name: Edrophonium chloride [USP:INN:BAN:JAN]
RN: 116-38-1
UNII: QO611KSM5P
InChIKey: BXKDSDJJOVIHMX-UHFFFAOYSA-N

Note

  • A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.

Molecular Formula

  • C10-H16-N-O.Cl

Molecular Weight

  • 201.6954
 

Classification Codes

  • Antidote (to Curare Principles)
  • Diagnostic Aid (Myasthenia Gravis)
  • Drug / Therapeutic Agent

Names and Synonyms

Name of Substance

  • Edrophonium chloride [USP:INN:BAN:JAN]

Synonyms

  • Ammonium, dimethylethyl(m-hydroxyphenyl)-, chloride
  • Antirex
  • Chlorure d'edrophonium
  • Chlorure d'edrophonium [INN-French]
  • Cloruro de edrofonio
  • Cloruro de edrofonio [INN-Spanish]
  • Edrofonio cloruro
  • Edrofonio cloruro [DCIT]
  • Edrophonii chloridum
  • Edrophonii chloridum [INN-Latin]
  • Edrophonium chloride
  • Edrophonium chloride preservative free
  • EINECS 204-138-4
  • Enlon
  • Ethyl(m-hydroxyphenyl)dimethylammonium chloride
  • Reversol
  • Tensilon
  • Tensilon chloride
  • Tensilon preservative free
  • UNII-QO611KSM5P

Systematic Names

  • Ammonium, ethyl(m-hydroxyphenyl)dimethyl-, chloride
  • Benzenaminium, N-ethyl-3-hydroxy-N,N-dimethyl-, chloride
  • Edrophonium chloride

Mixture Name

  • Enlon Plus

Registry Numbers

CAS Registry Number

  • 116-38-1

FDA UNII

  • QO611KSM5P

Related Registry Number

  • 312-48-1 (Parent)

System Generated Number

  • 0000116381

Molecular Formulas

Molecular Formula

  • C10-H16-N-O.Cl

Molecular Formula Fragments

  • C10-H16-N-O
  • Cl
  • COMPONENT

Structure Descriptors

InChI

1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H

InChIKey

BXKDSDJJOVIHMX-UHFFFAOYSA-N

Smiles

[Cl-].CC[N+](C)(C)c1cccc(O)c1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 30mg/kg (30mg/kg)   Pharmaceutical Chemistry Journal Vol. 10, Pg. 327, 1976.
mouse LD50 intravenous 8500ug/kg (8.5mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 115, Pg. 185, 1955.
mouse LD50 subcutaneous 52mg/kg (52mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Journal of Pharmacology and Experimental Therapeutics. Vol. 123, Pg. 121, 1958.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -2.950 (none)   EST
Atmospheric OH Rate Constant 1.86E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.