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Substance Name: Dimefline [INN:BAN]
RN: 1165-48-6
UNII: 9WII5M0DU3
InChIKey: ZXFQRFXLFWWKLX-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C20-H21-N-O3

Molecular Weight

  • 323.39
 
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Names and Synonyms

Name of Substance

  • Dimefline
  • Dimefline [INN:BAN]

Synonyms

  • 4H-1-Benzopyran-4-one, 8-((dimethylamino)methyl)-7-methoxy-3-methyl-2-phenyl-
  • 5-18-12-00083 (Beilstein Handbook Reference)
  • 8-((Dimethylamino)methyl)-7-methoxy-3-methyl-2-phenyl-4H-1-benzopyran-4-one
  • 8-((Dimethylamino)methyl)-7-methoxy-3-methyl-2-phenylflavone
  • 8-(Dimethylaminomethyl)-7-methoxy-3-methylflavone
  • 8-Dimethylaminomethyl-7-methoxy-3-methyl-2-phenylchromone
  • BRN 1395114
  • Dimeflin
  • Dimeflina
  • Dimeflina [INN-Spanish]
  • Dimefline
  • Dimeflinum
  • Dimeflinum [INN-Latin]
  • Dimelfin
  • EINECS 214-616-4
  • Flavone, 8-(dimethylaminomethyl)-7-methoxy-3-methyl-
  • HSDB 2110
  • Malivan
  • N-(7-Methoxy-3-methyl-4-oxo-2-phenyl-4H-chromen-8-yl)methyl-N,N-dimethylamine
  • NSC 169869
  • Reanimil
  • Remeflin (VAN)
  • UNII-9WII5M0DU3

Systematic Names

  • 3-Methyl-7-methoxy-8-dimethylamino-methylflavone
  • 4H-1-Benzopyran-4-one, 8-((dimethylamino)methyl)-7-methoxy-3-methyl-2-phenyl- (9CI)
  • 8-((Dimethylamino)methyl)-7-methoxy-3-methylflavone
  • Flavone, 8-(dimethylaminomethyl)-7-methoxy-3-methyl-

Registry Numbers

CAS Registry Number

  • 1165-48-6

FDA UNII

  • 9WII5M0DU3

Related Registry Number

  • 2740-04-7 (hydrochloride)

System Generated Number

  • 0001165486

Structure Descriptors

InChI

1S/C20H21NO3/c1-13-18(22)15-10-11-17(23-4)16(12-21(2)3)20(15)24-19(13)14-8-6-5-7-9-14/h5-11H,12H2,1-4H3

InChIKey

ZXFQRFXLFWWKLX-UHFFFAOYSA-N

Smiles

c12c(c(ccc1c(c(C)c(o2)c1ccccc1)=O)OC)CN(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 1mg/kg (1mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 1, Pg. 423, 1964.
dog LD50 oral 15gm/kg (15000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 1, Pg. 168, 1967.
dog LDLo intravenous 1mg/kg (1mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: REGIDITY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 1, Pg. 423, 1964.
hamster LD50 intraperitoneal 9mg/kg (9mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 1, Pg. 423, 1964.
hamster LD50 oral 25mg/kg (25mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 1, Pg. 423, 1964.
hamster LD50 subcutaneous 12mg/kg (12mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 1, Pg. 423, 1964.
mouse LD50 intraperitoneal 4800ug/kg (4.8mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Medicinal and Pharmaceutical Chemistry. Vol. 3, Pg. 471, 1961.
mouse LD50 intravenous 1500ug/kg (1.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: REGIDITY
Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 1, Pg. 423, 1964.
mouse LD50 oral 12mg/kg (12mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 1, Pg. 423, 1964.
mouse LD50 subcutaneous 4mg/kg (4mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: REGIDITY
Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 1, Pg. 423, 1964.
rabbit LDLo intravenous 2mg/kg (2mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: REGIDITY
Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 1, Pg. 423, 1964.
rat LD50 intraperitoneal 6mg/kg (6mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat LD50 intravenous 1800ug/kg (1.8mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: REGIDITY
Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 1, Pg. 423, 1964.
rat LD50 oral 40mg/kg (40mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: REGIDITY
Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 1, Pg. 423, 1964.
rat LD50 rectal 10mg/kg (10mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: REGIDITY
Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 1, Pg. 423, 1964.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 109.5 deg C   EXP
log P (octanol-water) 3.65 (none)   EXP
Water Solubility 69.6 mg/L 25 EST
Vapor Pressure 2.10E-08 mm Hg 25 EST
Henry's Law Constant 1.83E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.17E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.