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Substance Name: ME 2303
RN: 116521-53-0
InChIKey: PQMIPLRIRFVQJZ-QBYYVRQOSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C34-H37-F-O15

Molecular Weight

  • 704.649
 
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Names and Synonyms

Name of Substance

  • ME 2303

Synonyms

  • 7-O-(2,6-Dideoxy-2-fluoro-alpha-L-talopyranosyl)adriamycinone-14-O-hemipimelate
  • 7-O-(2,6-Dideoxy-2-fluoro-alpha-L-talopyranosyl)pimelyladriamycinone
  • FAD-104
  • FT-Adm
  • ME2303
  • RTECS MN0140000

Systematic Name

  • Heptanedioic acid, mono(2-(4-((2,6-dideoxy-2-fluoro-alpha-L-talopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)-2-oxoethyl) ester, (2S-cis)-

Registry Numbers

CAS Registry Number

  • 116521-53-0

System Generated Number

  • 0116521530

Structure Descriptors

InChI

1S/C34H37FO15/c1-14-27(40)32(45)26(35)33(49-14)50-18-12-34(46,19(36)13-48-21(39)10-5-3-4-9-20(37)38)11-16-23(18)31(44)25-24(29(16)42)28(41)15-7-6-8-17(47-2)22(15)30(25)43/h6-8,14,18,26-27,32-33,40,42,44-46H,3-5,9-13H2,1-2H3,(H,37,38)/t14-,18-,26+,27+,32-,33-,34-/m0/s1

InChIKey

PQMIPLRIRFVQJZ-QBYYVRQOSA-N

Smiles

c1ccc2C(c3c(c(c4c(c3O)C[C@@](O)(C(COC(CCCCCC(O)=O)=O)=O)C[C@@H]4O[C@H]3[C@@H]([C@@H]([C@@H]([C@@H](O3)C)O)O)F)O)C(c2c1OC)=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 72800ug/kg (72.8mg/kg)   Drugs of the Future. Vol. 14, Pg. 756, 1989.
mouse LD50 intravenous 138mg/kg (138mg/kg) BEHAVIORAL: MUSCLE WEAKNESS Drugs under Experimental and Clinical Research. Vol. 14, Pg. 435, 1988.
rat LD50 intravenous 179mg/kg (179mg/kg) BEHAVIORAL: MUSCLE WEAKNESS Drugs under Experimental and Clinical Research. Vol. 14, Pg. 435, 1988.