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Substance Name: Duloxetine [INN:BAN]
RN: 116539-59-4
UNII: O5TNM5N07U
InChIKey: ZEUITGRIYCTCEM-KRWDZBQOSA-N

Note

  • NCI: ... duloxetine, a fluoxetine derivative belonging to the class of selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors (SSNRIs) and exhibiting antidepressant activity. Duloxetine selectively prevents the reuptake of 5-HT and NE via transporter complexes on the pre-synaptic membrane, thereby increasing the level of these neurotransmitters within the synaptic cleft. As a result, this agent potentiates serotonergic and noradrenergic activities in the central nervous system, and alleviates depression and neuropathy sensations, such as pain and tingling. Furthermore, duloxetine does not show significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and gamma-aminobutyric acid (GABA) receptors. ... (NCI Thesaurus)

Molecular Formula

  • C18-H19-N-O-S

Molecular Weight

  • 297.4201
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Uptake Inhibitors
  • Analgesics
  • Antidepressant
  • Antidepressive Agents
  • Central Nervous System Agents
  • Dopamine Agents
  • Dopamine Uptake Inhibitors
  • Membrane Transport Modulators
  • Neurotransmitter Agents
  • Neurotransmitter Uptake Inhibitors
  • Peripheral Nervous System Agents
  • Psychotropic Drugs
  • Sensory System Agents
  • Serotonin Agents
  • Serotonin Uptake Inhibitors
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Names and Synonyms

Name of Substance

  • Duloxetine
  • Duloxetine [INN:BAN]

Synonyms

  • (S)-Duloxetine
  • (S)-N-Methyl-gamma-(1-naphthalenyloxy)-2-thiophenepropanamine
  • Ariclaim
  • Duloxetine
  • Duloxetine Boehringer Ingelheim
  • HSDB 7368
  • LY 248686
  • UNII-O5TNM5N07U
  • Xeristar
  • Yentreve

Systematic Names

  • 2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-, (gammaS)-
  • 2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-, (S)-

Registry Numbers

CAS Registry Number

  • 116539-59-4

FDA UNII

  • O5TNM5N07U

System Generated Number

  • 0116539594

Structure Descriptors

InChI

InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1

InChIKey

ZEUITGRIYCTCEM-KRWDZBQOSA-N

Smiles

CNCC[C@H](Oc1cccc2ccccc12)c3cccs3