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Substance Name: Vorsetzumab Mafodotin [USAN]
RN: 1165741-01-4
UNII: 699619YVTQ
InChIKey: BXTJCSYMGFJEID-XMTADJHZSA-N

Molecular Formula

  • C6476-H10006-N1726-O2028-S50. 3-5(C49-H78-N6-O11)

Molecular Weight

  • 1046.3297
 
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Names and Synonyms

Name of Substance

  • Vorsetuzumab mafodotin [USAN:INN]
  • Vorsetzumab Mafodotin [USAN]

Synonyms

  • Immunoglobulin G1, anti-(CD antigen CD70) (human-mouse monoclonal h1F6 heavy chain), disulfide with human-mouse monoclonal h1F6 light chain, dimer thioether with L-Phenylalanine, N-(6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl)-N-methyl-L- valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(alphaR,betaR,2S)-beta- methoxy-alpha-methyl-2-pyrrolidinepropanoyl-
  • SGN 75
  • SGN-75
  • UNII-699619YVTQ
  • Vorsetuzumab mafodotin
  • Vorsetzumab Mafodotin

Systematic Name

  • Humanized mouse monoclonal immunoglobulin G1 anti-(human CD70 antigen) linked via thioether bonds to an average of 3 to 5 molecules of mafodotin: tetrakis(SCys- ((3RS)-1-(6-(((1S)-1-(((1S)-1-(((1S,2R)-4-((2S)-2-((1R,3R)-3-(((1S)-1-carboxy-2- phenylethyl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-2-methoxy-1-((1S)- 1-methylpropyl)-4-oxobutyl)methylcarbamoyl)-2-methylpropyl)carbamoyl)-2- methylpropyl)methylamino)-6-oxohexyl)-2,5-dioxopyrrolidin-3-yl))immunoglobulin G1, anti-(human CD70 antigen (CD27 ligand, tumor necrosis factor ligand superfamily member 7)); humanized mouse monoclonal h1F6 gamma heavy chain (221-218')-disulfide with humanized mouse monoclonal h1F6 kappa light chain dimer (227-227'':230-230'')- bisdisulfide

Registry Numbers

CAS Registry Number

  • 1165741-01-4

FDA UNII

  • 699619YVTQ

System Generated Number

  • 1165741014

Structure Descriptors

InChI

1S/C52H83N7O13S/c1-12-32(6)45(38(71-10)27-41(61)58-25-19-22-37(58)46(72-11)33(7)47(63)54-36(52(69)70)26-34-20-15-13-16-21-34)57(9)50(66)43(30(2)3)55-48(64)44(31(4)5)56(8)40(60)23-17-14-18-24-59-42(62)28-39(49(59)65)73-29-35(53)51(67)68/h13,15-16,20-21,30-33,35-39,43-46H,12,14,17-19,22-29,53H2,1-11H3,(H,54,63)(H,55,64)(H,67,68)(H,69,70)/t32-,33+,35-,36-,37-,38+,39?,43-,44-,45-,46+/m0/s1

InChIKey

BXTJCSYMGFJEID-XMTADJHZSA-N

Smiles

CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCN3C(=O)CC(C3=O)SC[C@@H](C(=O)O)N