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Substance Name: Mibefradil [INN:BAN]
RN: 116644-53-2
UNII: 27B90X776A
InChIKey: HBNPJJILLOYFJU-VMPREFPWSA-N

Note

  • A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE.

Molecular Formula

  • C29-H38-F-N3-O3

Molecular Weight

  • 495.635
 

Classification Codes

  • Antihypertensive Agents
  • Calcium Channel Blockers
  • Cardiovascular Agents
  • Cytochrome P-450 CYP1A2 Inhibitors
  • Cytochrome P-450 Enzyme Inhibitors
  • Enzyme Inhibitors
  • Membrane Transport Modulators
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Mibefradil
  • Mibefradil [INN:BAN]

MeSH Heading

  • Mibefradil

Synonyms

  • (1S-cis)-2-(2-((3-(1H-Benzimidazol-2-yl)propyl)methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetate
  • 2-(2-((3-(1H-Benzimidazol-2-yl)propyl)methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetate (1S-cis)-
  • Mibefradil
  • Ro 40 5967
  • Ro 40-5967
  • Ro 405967
  • UNII-27B90X776A

Systematic Name

  • Acetic acid, methoxy-, 2-(2-((3-(1H-benzimidazol-2-yl)propyl)methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, (1S-cis)-

Registry Numbers

CAS Registry Number

  • 116644-53-2

FDA UNII

  • 27B90X776A

Related Registry Number

  • 116666-63-8 (dihydrochloride)

System Generated Number

  • 0116644532

Structure Descriptors

InChI

1S/C29H38FN3O3/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32)/t28-,29-/m0/s1

InChIKey

HBNPJJILLOYFJU-VMPREFPWSA-N

Smiles

C1[C@@]([C@H](c2c(cc(F)cc2)C1)C(C)C)(CC[N@@](CCCc1[nH]c2ccccc2n1)C)OC(COC)=O