Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Mibefradil dihydrochloride [USAN]
RN: 116666-63-8
UNII: 842TUP3PQ8
InChIKey: MTJLQTFHJIHXIX-GDUXWEAWSA-N

Note

  • A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE.

Molecular Formula

  • C29-H38-F-N3-O3.2Cl-H

Molecular Weight

  • 568.557
 

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect
  • Vasodilator
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Mibefradil
  • Mibefradil dihydrochloride
  • Mibefradil dihydrochloride [USAN]

Synonyms

  • (1S,2S)-(2-((3-(2-Benzimidazolyl)propyl)methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate, dihydrochloride
  • Acetic acid, methoxy-, 2-(2-((3-(1H-benzimidazol-2-yl)propyl)methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, dihydrochloride, (1S-cis)-
  • Mibefradil dihydrochloride
  • Mibefradil HCl
  • Posicor
  • Ro 40-5967
  • RO 40-5967/001
  • UNII-842TUP3PQ8

Systematic Name

  • Acetic acid, methoxy-, 2-(2-((3-(1H-benzimidazol-2-yl)propyl)methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, dihydrochloride, (1S-cis)-

Registry Numbers

CAS Registry Number

  • 116666-63-8

FDA UNII

  • 842TUP3PQ8

Related Registry Number

  • 116644-53-2 (Parent)

System Generated Number

  • 0116666638

Molecular Formulas

Molecular Formula

  • C29-H38-F-N3-O3.2Cl-H

Molecular Formula Fragments

  • C29-H38-F-N3-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C29H38FN3O3.2ClH/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26;;/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32);2*1H/t28-,29-;;/m0../s1

InChIKey

MTJLQTFHJIHXIX-GDUXWEAWSA-N

Smiles

C1[C@@]([C@H](c2c(cc(F)cc2)C1)C(C)C)(CC[N@@](CCCc1[nH]c2ccccc2n1)C)OC(COC)=O.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 35mg/kg (35mg/kg)   Cardiovascular Drug Reviews. Vol. 9, Pg. 4, 1991.
mouse LD50 oral > 800mg/kg (800mg/kg)   Cardiovascular Drug Reviews. Vol. 9, Pg. 4, 1991.
rat LD50 intravenous 23mg/kg (23mg/kg)   Cardiovascular Drug Reviews. Vol. 9, Pg. 4, 1991.
rat LD50 oral > 800mg/kg (800mg/kg)   Cardiovascular Drug Reviews. Vol. 9, Pg. 4, 1991.