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Substance Name: Trifluoperazine [INN:BAN]
RN: 117-89-5
UNII: 214IZI85K3
InChIKey: ZEWQUBUPAILYHI-UHFFFAOYSA-N

Note

  • A phenothiazine with actions similar to CHLORPROMAZINE. It is used as an antipsychotic and an antiemetic.

Molecular Formula

  • C21-H24-F3-N3-S

Molecular Weight

  • 407.5016
 

Classification Codes

  • Antiemetics
  • Antipsychotic Agents
  • Autonomic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Dopamine Agents
  • Dopamine Antagonists
  • Drug / Therapeutic Agent
  • Gastrointestinal Agents
  • Mutation Data
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Psychotropic Drugs
  • Reproductive Effect
  • Tranquilizing Agents

Names and Synonyms

Name of Substance

  • Trifluoperazine
  • Trifluoperazine [INN:BAN]

MeSH Heading

  • Trifluoperazine

Synonyms

  • 10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)phenothiazine
  • 10-(gamma-(N'-Methylpiperazino)propyl)-2-trifluoromethylphenothiazine
  • 10H-Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-
  • 2-Trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine
  • CCRIS 6994
  • EINECS 204-219-4
  • Flurazine
  • HSDB 3195
  • NSC 17474
  • NSC 46061
  • Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-
  • RP 7623
  • TFP
  • Trifluoperazin
  • Trifluoperazina
  • Trifluoperazina [INN-Spanish]
  • Trifluoperazina [Italian]
  • Trifluoperazine
  • Trifluoperazinum
  • Trifluoperazinum [INN-Latin]
  • Trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine
  • Trifluoromethylperazine
  • Trifluoroperazine
  • Trifluperazine
  • Triflurin
  • Triperazine
  • UNII-214IZI85K3

Systematic Names

  • 10H-Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-
  • Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-
  • Trifluoperazine

Registry Numbers

CAS Registry Number

  • 117-89-5

FDA UNII

  • 214IZI85K3

System Generated Number

  • 0000117895

Structure Descriptors

InChI

1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3

InChIKey

ZEWQUBUPAILYHI-UHFFFAOYSA-N

Smiles

CN1CCN(CC1)CCCN2c3ccccc3Sc4c2cc(cc4)C(F)(F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 120mg/kg (120mg/kg)   Neuropharmacology. Vol. 9, Pg. 235, 1970.
mouse LD50 intravenous 29mg/kg (29mg/kg)   Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.
mouse LD50 oral 1350mg/kg (1350mg/kg)   Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 5.03 (none)   EXP
Water Solubility 12.2 mg/L 24 EXP
Vapor Pressure 7.94E-09 mm Hg 25 EST
Henry's Law Constant 1.26E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.70E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.