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Substance Name: 1,2-Propanediol, 3-(4-phenyl-1-piperazinyl)-, (R,S)-
RN: 117067-01-3
InChIKey: PTVWPYVOOKLBCG-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C13-H20-N2-O2

Molecular Weight

  • 236.313
 
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Names and Synonyms

Synonyms

  • (+-)-Dropropizine
  • (R,S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol

Systematic Name

  • 1,2-Propanediol, 3-(4-phenyl-1-piperazinyl)-, (R,S)-

Registry Numbers

CAS Registry Number

  • 117067-01-3

System Generated Number

  • 0117067013

Structure Descriptors

InChI

1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2

InChIKey

PTVWPYVOOKLBCG-UHFFFAOYSA-N

Smiles

C([C@@H](CN1CCN(CC1)c1ccccc1)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 2697mg/kg (2697mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1150, 1988.
mouse LD50 intraperitoneal 340mg/kg (340mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1150, 1988.
mouse LD50 oral 900mg/kg (900mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1150, 1988.
rat LD50 intraperitoneal 393mg/kg (393mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1150, 1988.
rat LD50 oral 607mg/kg (607mg/kg) GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1150, 1988.