Skip Navigation
ChemIDplus A TOXNET DATABASE Lite•Browse•Advanced

Substance Name: Flurazepam hydrochloride [USAN:USP:JAN]
RN: 1172-18-5
UNII: 756RDM536M
InChIKey: ZIIJJOPLRSCQNX-UHFFFAOYSA-N

Note

  • A benzodiazepine derivative used mainly as a hypnotic.

Molecular Formula

  • C21-H23-Cl-F-N3-O.2Cl-H

Molecular Weight

  • 460.8055
 

Classification Codes

  • Anticonvulsant
  • Drug / Therapeutic Agent
  • Relaxant (Muscle)
  • Sedative-Hypnotic
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Regulatory Agencies (Superlist Locators)

Other Resources (Internet Locators)


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Flurazepam dihydrochloride
  • Flurazepam hydrochloride [USAN:USP:JAN]

Synonyms

  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-, dihydrochloride
  • 7-Chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride
  • Benozil
  • Dalmadorm
  • Dalmane
  • Dalmate
  • EINECS 214-630-0
  • Felison
  • Flurazepam dihydrochloride
  • Flurazepam HCl
  • Flurazepam hydrochloride
  • ID 480
  • Insumin
  • Insumin dihydrochloride
  • Linzac
  • Lunipax
  • Natam
  • NSC-78559
  • Ro 5-6901
  • Somlan
  • UNII-756RDM536M

Systematic Names

  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-, dihydrochloride
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-, 1,3-dihydro-, dihydrochloride
  • Flurazepam hydrochloride

Superlist Names

  • Dalmane
  • DEA No. 2767
  • Flurazepam
  • Flurazepam hydrochloride

Registry Numbers

CAS Registry Number

  • 1172-18-5

FDA UNII

  • 756RDM536M

Related Registry Number

  • 17617-23-1 (Parent)

System Generated Number

  • 0001172185

Molecular Formulas

Molecular Formula

  • C21-H23-Cl-F-N3-O.2Cl-H

Molecular Formula Fragments

  • C21-H23-Cl-F-N3-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H23ClFN3O.2ClH/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23;;/h5-10,13H,3-4,11-12,14H2,1-2H3;2*1H

InChIKey

ZIIJJOPLRSCQNX-UHFFFAOYSA-N

Smiles

CCN(CC)CCN1c2ccc(cc2C(=NCC1=O)c3ccccc3F)Cl.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 186mg/kg (186mg/kg)   Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
mouse LD50 intravenous 59100ug/kg (59.1mg/kg)   Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
mouse LD50 oral 596mg/kg (596mg/kg)   Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
mouse LD50 subcutaneous 440mg/kg (440mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)		 Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977.
rabbit LD50 oral 568mg/kg (568mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 178, Pg. 216, 1969.
rat LD50 intraperitoneal 152mg/kg (152mg/kg)   Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
rat LD50 intravenous 38700ug/kg (38.7mg/kg)   Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
rat LD50 oral 879mg/kg (879mg/kg)   Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
rat LD50 subcutaneous 859mg/kg (859mg/kg)   Drugs in Japan Vol. 6, Pg. 706, 1982.