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Substance Name: Flurazepam hydrochloride [USAN:USP:JAN]
RN: 1172-18-5
UNII: 756RDM536M
InChIKey: ZIIJJOPLRSCQNX-UHFFFAOYSA-N

Note

  • A benzodiazepine derivative used mainly as a hypnotic.

Molecular Formula

  • C21-H23-Cl-F-N3-O.2Cl-H

Molecular Weight

  • 460.8055
 

Classification Codes

  • Anticonvulsant
  • Drug / Therapeutic Agent
  • Relaxant (Muscle)
  • Sedative-Hypnotic
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Names and Synonyms

Name of Substance

  • Flurazepam dihydrochloride
  • Flurazepam hydrochloride [USAN:USP:JAN]

Synonyms

  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-, dihydrochloride
  • 7-Chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride
  • Benozil
  • Dalmadorm
  • Dalmane
  • Dalmate
  • EINECS 214-630-0
  • Felison
  • Flurazepam dihydrochloride
  • Flurazepam HCl
  • Flurazepam hydrochloride
  • ID 480
  • Insumin
  • Insumin dihydrochloride
  • Linzac
  • Lunipax
  • Natam
  • NSC-78559
  • Ro 5-6901
  • Somlan
  • UNII-756RDM536M

Systematic Names

  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-, dihydrochloride
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-, 1,3-dihydro-, dihydrochloride
  • Flurazepam hydrochloride

Superlist Names

  • Dalmane
  • DEA No. 2767
  • Flurazepam
  • Flurazepam hydrochloride

Registry Numbers

CAS Registry Number

  • 1172-18-5

FDA UNII

  • 756RDM536M

Related Registry Number

  • 17617-23-1 (Parent)

System Generated Number

  • 0001172185

Molecular Formulas

Molecular Formula

  • C21-H23-Cl-F-N3-O.2Cl-H

Molecular Formula Fragments

  • C21-H23-Cl-F-N3-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H23ClFN3O.2ClH/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23;;/h5-10,13H,3-4,11-12,14H2,1-2H3;2*1H

InChIKey

ZIIJJOPLRSCQNX-UHFFFAOYSA-N

Smiles

CCN(CC)CCN1c2ccc(cc2C(=NCC1=O)c3ccccc3F)Cl.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 186mg/kg (186mg/kg)   Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
mouse LD50 intravenous 59100ug/kg (59.1mg/kg)   Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
mouse LD50 oral 596mg/kg (596mg/kg)   Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
mouse LD50 subcutaneous 440mg/kg (440mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977.
rabbit LD50 oral 568mg/kg (568mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 178, Pg. 216, 1969.
rat LD50 intraperitoneal 152mg/kg (152mg/kg)   Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
rat LD50 intravenous 38700ug/kg (38.7mg/kg)   Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
rat LD50 oral 879mg/kg (879mg/kg)   Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
rat LD50 subcutaneous 859mg/kg (859mg/kg)   Drugs in Japan Vol. 6, Pg. 706, 1982.