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Substance Name: 2,4-Methanoglutamate
RN: 117488-23-0
InChIKey: GGMYWPBNZXRMME-MYNUVTBMSA-N

Note

  • Selective N-methyl-D-aspartate receptor agonist; inhibits high affinity L-glutamic acid uptake into rat cortical synaptosomes.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C6-H9-N-O4.H2-O

Molecular Weight

  • 159.1401
 
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Names and Synonyms

Name of Substance

  • 2,4-Methanoglutamate

Synonym

  • trans-1-Aminocyclobutane-1,3-dicarboxylic acid hydrate

Systematic Name

  • 1,3-Cyclobutanedicarboxylic acid, 1-amino-, trans-, hydrate

Registry Numbers

CAS Registry Number

  • 117488-23-0

System Generated Number

  • 0117488230

Molecular Formulas

Molecular Formula

  • C6-H9-N-O4.H2-O

Molecular Formula Fragments

  • C6-H9-N-O4
  • COMPONENT
  • H2-O

Structure Descriptors

InChI

1S/C6H9NO4/c7-6(5(10)11)1-3(2-6)4(8)9/h3H,1-2,7H2,(H,8,9)(H,10,11)/t3-,6+

InChIKey

GGMYWPBNZXRMME-MYNUVTBMSA-N

Smiles

C1[C@@](C[C@@H]1C(=O)O)(N)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo intraperitoneal 180mg/kg (180mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Medicinal Chemistry. Vol. 33, Pg. 2905, 1990.