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Substance Name: EMD 273063 antibody, human
RN: 1178530-69-2

Note

  • Induced immune activation and was associated with reversible clinical toxicities at the MTD of 7.5 mg/m2/d in melanoma patients.

    NCI: hu14.18-IL2 fusion protein A recombinant protein consisting of the hu14.18 monoclonal antibody fused to the cytokine interleukin-2 (IL2) with potential antineoplastic activity. The monoclonal antibody portion of the hu14.18-IL2 fusion protein binds to tumor cells expressing the GD2 antigen (melanoma, neuroblastoma and certain other tumors); the Fc component of the fusion protein antibody moiety and natural killer (NK) cells mediate antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cellular cytotoxicity (CDCC) towards GD2-expressing tumor cells. The localized IL2 moiety of the fusion protein stimulates NK and T-cell antitumor cellular immune responses. (NCI Thesaurus)
 
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Names and Synonyms

Name of Substance

  • EMD 273063 antibody, human

Synonyms

  • EMD 273063
  • Hu 14.18IL2
  • Hu14.18-IL2

Registry Numbers

CAS Registry Number

  • 1178530-69-2

System Generated Number

  • 1178530692