Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Thiethylperazine maleate [USAN:USP]
RN: 1179-69-7
UNII: RUK64CF26E
InChIKey: RVBRTNPNFYFDMZ-SPIKMXEPSA-N

Note

  • A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457)

Molecular Formula

  • C22-H29-N3-S2.2C4-H4-O4

Molecular Weight

  • 631.7673
 

Classification Codes

  • Anti-Emetic
  • Drug / Therapeutic Agent
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Thiethylperazine maleate [USAN:USP]

Synonyms

  • 10H-Phenothiazine, 2-(ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)-, (Z)-2-butenedioate
  • 10H-Phenothiazine, 2-(ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)-, (Z)-2-butenedioate (1:2)
  • 2-(Ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine dimaleate
  • 2-(Ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine maleate (1:2)
  • 2-Ethylmercapto-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine dimaleate
  • 3-Ethylmercapto-10-(1'-methylpiperazinyl-4'-propyl)phenothiazine dimaleate
  • EINECS 214-648-9
  • GS-95
  • Norzine
  • NSC-130044
  • Phenothiazine, 2-(ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)-, dimaleate
  • Thiethylperazine dimaleate
  • Thiethylperazine maleate
  • Thietylperazine maleate
  • Tietylperazine malate
  • Tietylperazine maleate
  • Torecan
  • Torecan bimaleate
  • Torecan dimaleate
  • Torecan maleate
  • Toresten
  • Tresten
  • UNII-RUK64CF26E

Systematic Names

  • 10H-Phenothiazine, 2-(ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)-, (Z)-2-butenedioate (1:2)
  • Phenothiazine, 2-(ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)-, maleate (1:2)
  • Thiethylperazine di(hydrogen maleate)

Registry Numbers

CAS Registry Number

  • 1179-69-7

FDA UNII

  • RUK64CF26E

Related Registry Number

  • 1420-55-9 (Parent)

System Generated Number

  • 0001179697

Molecular Formulas

Molecular Formula

  • C22-H29-N3-S2.2C4-H4-O4

Molecular Formula Fragments

  • C22-H29-N3-S2
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C22H29N3S2.2C4H4O4/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24;2*5-3(6)1-2-4(7)8/h4-5,7-10,17H,3,6,11-16H2,1-2H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-

InChIKey

RVBRTNPNFYFDMZ-SPIKMXEPSA-N

Smiles

CCSc1cc2c(cc1)Sc3c(cccc3)N2CCCN4CCN(CC4)C.C(=C\C(=O)O)\C(=O)O.C(=C\C(=O)O)\C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 217mg/kg (217mg/kg)   Medicina Experimentalis. Vol. 4, Pg. 145, 1961.
mouse LD50 intravenous 93mg/kg (93mg/kg)   Medicina Experimentalis. Vol. 4, Pg. 145, 1961.
mouse LD50 oral 680mg/kg (680mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 51, 1972.
rabbit LD50 intravenous 27mg/kg (27mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 51, 1972.
rabbit LD50 oral 1050mg/kg (1050mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 51, 1972.
rat LD50 intravenous 90mg/kg (90mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 51, 1972.
rat LD50 oral 1260mg/kg (1260mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 51, 1972.