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Substance Name: Tazarotene [USAN:INN:BAN]
RN: 118292-40-3
UNII: 81BDR9Y8PS
InChIKey: OGQICQVSFDPSEI-UHFFFAOYSA-N

Note

  • A topical acetylenic retinoid; a topical kerytolytic.

Molecular Formula

  • C21-H21-N-O2-S

Molecular Weight

  • 351.468
 

Classification Codes

  • Dermatologic Agents
  • Keratolytic
  • Keratolytic Agents
  • Noxae
  • Teratogens

Names and Synonyms

Name of Substance

  • Tazarotene
  • Tazarotene [USAN:INN:BAN]

Synonyms

  • AGN 190168
  • AGN-190168
  • Avage
  • Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate
  • Fabior
  • Tazarotene
  • Tazorac
  • UNII-81BDR9Y8PS
  • Zorac

Systematic Name

  • 3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-, ethyl ester

Registry Numbers

CAS Registry Number

  • 118292-40-3

FDA UNII

  • 81BDR9Y8PS

System Generated Number

  • 0118292403

Structure Descriptors

InChI

InChI=1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3

InChIKey

OGQICQVSFDPSEI-UHFFFAOYSA-N

Smiles

CCOC(=O)c1ccc(nc1)C#Cc2ccc3SCCC(C)(C)c3c2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD oral > 2gm/kg (2000mg/kg)   Journal of the American Academy of Dermatology. Vol. 37(Suppl), Pg. S25, 1997.