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Substance Name: KW 2149
RN: 118359-59-4
InChIKey: BIOSTZMAOGCGSC-CYUGEGSCSA-N

Note

  • Derivative of mitomycin C.

Classification Codes

  • Antibiotics, Antineoplastic
  • Antineoplastic Agents
  • Drug / Therapeutic Agent

Molecular Formula

  • C24-H34-N6-O8-S2

Molecular Weight

  • 598.699
 
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Names and Synonyms

Name of Substance

  • KW 2149

Synonyms

  • 7-N-((2-((2-(R-L-Glutamylamino)ethyl)dithio)ethyl))mitomycin C
  • 7-N-(2-((2-(gamma-L-Glutamylamino)ethyl)dithio)ethyl)mitomycin C
  • KT6149
  • KW 2149

Systematic Names

  • L-Glutamine, N-(2-((2-(((1aS,8S,8aR,8bS)-8-(((aminocarbonyl)oxy)methyl)-1,1a,2,4,7,8,8a,8b-octahydro-8a-methoxy-5-methyl-4,7-dioxoazirino(2',3':3,4)pyrrolo(1,2-a)indol-6-yl)amino)ethyl)dithio)ethyl)-
  • L-Glutamine, N-(2-((2-((8-(((aminocarbonyl)oxy)methyl)-1,1a,2,4,7,8,8a,8b-octahydro-8a-methoxy-5-methyl-4,7-dioxoazirino(2',3':3,4)pyrrolo(1,2-a)indol-6-yl)amino)ethyl)dithio)ethyl)-, (1aS-(1a-alpha,8-beta,8a-alpha,8b-alpha))-

Registry Numbers

CAS Registry Number

  • 118359-59-4

System Generated Number

  • 0118359594

Structure Descriptors

InChI

1S/C24H34N6O8S2/c1-11-17(28-6-8-40-39-7-5-27-15(31)4-3-13(25)22(34)35)20(33)16-12(10-38-23(26)36)24(37-2)21-14(29-21)9-30(24)18(16)19(11)32/h12-14,21,28-29H,3-10,25H2,1-2H3,(H2,26,36)(H,27,31)(H,34,35)/t12-,13+,14+,21+,24-/m1/s1

InChIKey

BIOSTZMAOGCGSC-CYUGEGSCSA-N

Smiles

OC([C@H](CCC(NCCSSCCNC1=C(C)C(C2=C(C1=O)[C@H]([C@@]1(N2C[C@H]2[C@H]1N2)OC)COC(N)=O)=O)=O)N)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 22500ug/kg (22.5mg/kg)   Chemical and Pharmaceutical Bulletin. Vol. 37, Pg. 1128, 1989.
mouse LD50 intravenous 19600ug/kg (19.6mg/kg)   Drugs of the Future. Vol. 14, Pg. 127, 1989.
mouse LD50 unreported 7500ug/kg (7.5mg/kg)   Gan to Kagaku Ryoho. Cancer and Chemotherapy. Vol. 16, Pg. 2189, 1989.