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Substance Name: Trametinib dimethyl sulfoxide [USAN]
RN: 1187431-43-1
UNII: BSB9VJ5TUT
InChIKey: OQUFJVRYDFIQBW-UHFFFAOYSA-N

Note

  • NCI: An orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MEK MAPK/ERK kinase) with potential antineoplastic activity. Trametinib specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor-mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity threonine/tyrosine kinases often upregulated in various cancer cell types, play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth. (NCI Thesaurus)

Molecular Formula

  • C26-H23-F-I-N5-O4.C2-H6-O-S

Molecular Weight

  • 693.5311
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents

Names and Synonyms

Name of Substance

  • Trametinib dimethyl sulfoxide [USAN]

Synonyms

  • Equimolecular combination of N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8- dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido(4,3-d)pyrimidin-1(2H)- yl)phenyl)acetamide with dimethyl-lambda(sup 4)-sulfanone
  • GSK1120212
  • GSK1120212B
  • JTP 74057
  • Mekinst
  • Trametinib dimethyl sulfoxide
  • Trametinib DMSO
  • UNII-BSB9VJ5TUT

Systematic Name

  • Acetamide, N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-3,4,6,7-tetrahydro-6,8- dimethyl-2,4,7-trioxopyrido(4,3-d)pyrimidin-1(2H)-yl)phenyl)-, compd. with 1,1'- sulfinylbis(methane) (1:1)

Registry Numbers

CAS Registry Number

  • 1187431-43-1

FDA UNII

  • BSB9VJ5TUT

Other Registry Number

  • 1204531-25-8

System Generated Number

  • 1187431431

Molecular Formulas

Molecular Formula

  • C26-H23-F-I-N5-O4.C2-H6-O-S

Molecular Formula Fragments

  • C2-H6-O-S
  • C26-H23-F-I-N5-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C26H23FIN5O4.C2H6OS/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34;1-4(2)3/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34);1-2H3

InChIKey

OQUFJVRYDFIQBW-UHFFFAOYSA-N

Smiles

Cc1c2c(c(n(c1=O)C)Nc3ccc(cc3F)I)c(=O)n(c(=O)n2c4cccc(c4)NC(=O)C)C5CC5.CS(=O)C