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Substance Name: Talimogene laherparepvec [USAN:INN]
RN: 1187560-31-1
UNII: 07730V90L6


  • NCI: An oncolytic, recombinant herpes simplex type-1 virus (HSV) encoding thuman cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with potential immunostimulating and antineoplastic activities. Upon administration, GM-CSF-encoding oncolytic HSV selectively infects and replicates in tumor cells, thereby inducing tumor cell lysis. In addition, expressed GM-CSF may stimulate a cytotoxic T cell response against tumor cells, resulting in immune-mediated tumor cell death in addition to HSV-mediated oncolytic tumor cell death. (NCI Thesaurus)

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
  • Antineoplastic Agents, Immunological
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Links to Resources

Names and Synonyms

Name of Substance

  • Talimogene laherparepvec [USAN:INN]


  • Imlygic
  • JS 1-34.5hGMCSF47pA
  • JS1 34.5-hGMCSF 47- pA-
  • JS1 34.5-hGMCSF47-pA-
  • OncoVEX
  • OncoVEX (GM-CSF)
  • T-VEC
  • Talimogene laherparepvec
  • Talminogene Laherparepvec
  • UNII-07730V90L6

Systematic Name

  • ICP34.5-, ICP47-deleted herpes simplex virus 1 (HSV-1) incorporating the human GM- CSF gene

Registry Numbers

CAS Registry Number

  • 1187560-31-1


  • 07730V90L6

System Generated Number

  • 1187560311