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Substance Name: Carglumic acid [USAN:INN]
RN: 1188-38-1
UNII: 5L0HB4V1EW
InChIKey: LCQLHJZYVOQKHU-VKHMYHEASA-N

Note

  • Used in therapy of neonatal hyperammonemia.

Classification Codes

  • Drug / Therapeutic Agent
  • Treatment of Hyperammonemia Due to N-Acetylglutamate Synthase (NAGS) Deficiency

Molecular Formula

  • C6-H10-N2-O5

Molecular Weight

  • 190.154
 

Names and Synonyms

Name of Substance

  • Carglumic acid [USAN:INN]
  • N-Carbamylglutamate

Synonyms

  • Carbaglu
  • Carbamino-L-glutamic acid
  • Carbamylglutamic acid
  • Carglumic acid
  • L-N-Carbamoylglutamic acid
  • N-Carbamoyl-L-glutamic acid
  • OE 312 (laboratory code designation)
  • UNII-5L0HB4V1EW
  • Ureidoglutaric acid

Systematic Names

  • Glutamic acid, N-carbamoyl-, L- (8CI)
  • L-Glutamic acid, N-(aminocarbonyl)-

Registry Numbers

CAS Registry Number

  • 1188-38-1

FDA UNII

  • 5L0HB4V1EW

System Generated Number

  • 0001188381

Structure Descriptors

InChI

1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1

InChIKey

LCQLHJZYVOQKHU-VKHMYHEASA-N

Smiles

C(CC(=O)O)[C@@H](C(=O)O)NC(=O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral > 1gm/kg (1000mg/kg)   Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(4), Pg. 32, 1990.