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Substance Name: Framycetin [INN:BAN:DCF]
RN: 119-04-0
UNII: 4BOC774388
InChIKey: PGBHMTALBVVCIT-VCIWKGPPSA-N

Note

  • A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)

Molecular Formula

  • C23-H46-N6-O13

Molecular Weight

  • 614.645
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Drug / Therapeutic Agent
  • Natural Product
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Names and Synonyms

Name of Substance

  • Framycetin
  • Framycetin [INN:BAN:DCF]

MeSH Heading

  • Framycetin

Synonyms

  • 4-18-00-07476 (Beilstein Handbook Reference)
  • Actilin
  • Actiline
  • Antibiotique
  • BRN 0101621
  • EINECS 204-292-2
  • Enterfram
  • Framicetina
  • Framicetina [INN-Spanish]
  • Framycetin
  • Framycetine
  • Framycetine [INN-French]
  • Framycetinum
  • Framycetinum [INN-Latin]
  • Framygen
  • Soframycin
  • Soframycine
  • UNII-4BOC774388

Systematic Names

  • Antibiotic produced by Streptomyces decaris. Neomycin B
  • D-Streptamine, O-2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-beta-D-ribofuranosyl-(1-5))-2-deoxy-
  • Framycetin
  • Neomycin B

Registry Numbers

CAS Registry Number

  • 119-04-0

FDA UNII

  • 4BOC774388

Other Registry Numbers

  • 11025-81-3
  • 1393-86-8

System Generated Number

  • 0000119040

Structure Descriptors

InChI

1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1

InChIKey

PGBHMTALBVVCIT-VCIWKGPPSA-N

Smiles

O1[C@H](O[C@H]2[C@H](O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]3[C@@H]([C@H]([C@@H]([C@@H](O3)CN)O)O)N)O)[C@H]([C@@H](C[C@@H]2N)N)O)[C@@H]([C@H]([C@@H](O)[C@H]1CN)O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 250mg/kg (250mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 741, 1978.
mouse LD50 intravenous 24mg/kg (24mg/kg)   Journal of Antibiotics. Vol. 27, Pg. 677, 1974.
mouse LD50 oral 1250mg/kg (1250mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 1, Pg. 127, 1980.
mouse LD50 subcutaneous 220mg/kg (220mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 2, Pg. 121, 1957.