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Substance Name: Buformin hydrochloride
RN: 1190-53-0
UNII: D947SXO87P
InChIKey: KKLWSPPIRBIEOV-UHFFFAOYSA-N

Note

  • An oral hypoglycemic agent that inhibits gluconeogenesis, increases glycolysis, and decreases glucose oxidation.

Molecular Formula

  • C6-H15-N5.Cl-H

Molecular Weight

  • 193.68
 

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Buformin hydrochloride

Synonyms

  • 1-Butyl-biguanid hydrochlorid
  • 1-Butyl-biguanid hydrochlorid [German]
  • 1-Butylbiguanide hydrochloride
  • 1-Butyldiguanide hydrochloride
  • Adebit
  • Andere
  • Biforon
  • Bigunal
  • Bufonamin
  • Buformin HCl
  • Buformin hydrochloride
  • Buformine HCl
  • Bulbonin
  • Butyl guanylguanidine
  • Butylbiguanide hydrochloride
  • DBV hydrochloride
  • Diabrin
  • Dibetos
  • EINECS 214-723-6
  • Glibutide
  • Gliporal
  • Glybutide
  • Insulamin
  • Krebon
  • N(sup 1)-n-Butylbiguanide hydrochloride
  • N-Butylbiguanide hydrochloride
  • NSC 113665
  • NSC 528218
  • Panformin
  • RTECS EB2702000
  • SB 103
  • Sindiatil
  • Tidemol
  • UNII-D947SXO87P
  • W37
  • Ziavetine

Systematic Names

  • 1-Butylbiguanide monohydrochloride
  • Biguanide, 1-butyl-, monohydrochloride
  • N-Butyl-imidodicarbonimidic diamide monohydrochloride (9CI)

Registry Numbers

CAS Registry Number

  • 1190-53-0

FDA UNII

  • D947SXO87P

System Generated Number

  • 0001190530

Molecular Formulas

Molecular Formula

  • C6-H15-N5.Cl-H

Molecular Formula Fragments

  • C6-H15-N5
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C6H15N5.ClH/c1-2-3-4-10-6(9)11-5(7)8;/h2-4H2,1H3,(H6,7,8,9,10,11);1H

InChIKey

KKLWSPPIRBIEOV-UHFFFAOYSA-N

Smiles

N(C(NC(=N)[NH2+])=N)CCCC.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 58mg/kg (58mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 314, 1962.
guinea pig LD50 subcutaneous 23mg/kg (23mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 314, 1962.
human TDLo oral 2857ug/kg (2.857mg/kg) BLOOD: OTHER CHANGES Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 7, Pg. 1504, 1965.
mouse LD50 intraperitoneal 74mg/kg (74mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toksikologicheskii Vestnik. Vol. (2), Pg. 41, 1993.
mouse LD50 intravenous 105mg/kg (105mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 314, 1962.
mouse LD50 oral 380mg/kg (380mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 314, 1962.
rat LD50 oral 320mg/kg (320mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 314, 1962.