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Substance Name: Flutrimazole [INN:BAN]
RN: 119006-77-8
UNII: 776S0UP252
InChIKey: QHMWCHQXCUNUAK-UHFFFAOYSA-N

Classification Codes

  • Anti-Infective Agents
  • Antifungal Agents
  • Drug / Therapeutic Agent

Molecular Formula

  • C22-H16-F2-N2

Molecular Weight

  • 346.3784
 
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Names and Synonyms

Name of Substance

  • Flutrimazole
  • Flutrimazole [INN:BAN]

Synonyms

  • 1-((2-Fluorophenyl)(4-fluorophenyl)phenylmethyl)-1H-imidazole
  • 1-(o-Fluoro-alpha-(p-fluorophenyl)-alpha-phenylbenzyl)imidazole
  • BRN 5383184
  • Flutrimazol
  • Flutrimazol [INN-Spanish]
  • Flutrimazole
  • Flutrimazolum
  • Flutrimazolum [INN-Latin]
  • UNII-776S0UP252
  • UR-4056

Systematic Names

  • 1-(o-Fluoro-alpha-(p-fluorophenyl)-alpha-phenylbenzyl)imidazole
  • 1H-Imidazole, 1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-

Registry Numbers

CAS Registry Number

  • 119006-77-8

FDA UNII

  • 776S0UP252

System Generated Number

  • 0119006778

Structure Descriptors

InChI

1S/C22H16F2N2/c23-19-12-10-18(11-13-19)22(26-15-14-25-16-26,17-6-2-1-3-7-17)20-8-4-5-9-21(20)24/h1-16H

InChIKey

QHMWCHQXCUNUAK-UHFFFAOYSA-N

Smiles

c1ccc(cc1)C(c2ccc(cc2)F)(c3ccccc3F)n4ccnc4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 2gm/kg (2000mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992.
mouse LD50 oral > 1gm/kg (1000mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992.
rat LD50 intraperitoneal 1079mg/kg (1079mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992.
rat LD50 oral 808mg/kg (808mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992.