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Substance Name: Topotecan hydrochloride [USAN]
RN: 119413-54-6
UNII: 956S425ZCY
InChIKey: DGHHQBMTXTWTJV-BQAIUKQQSA-N

Note

  • An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.

Molecular Formula

  • C23-H23-N3-O5.Cl-H

Molecular Weight

  • 457.9116
 

Classification Code

  • Antineoplastic (DNA Topoisomerase I Inhibitor)

Names and Synonyms

Name of Substance

  • Topotecan hydrochloride [USAN]

MeSH Heading

  • Topotecan

Synonyms

  • (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione monohydrochloride
  • DRG-0288
  • Hycamptamine hydrochloride
  • Hycamtin
  • SK&F S-104864-A
  • Topotecan HCl
  • Topotecan hydrochloride
  • Topotecan monohydrochloride
  • UNII-956S425ZCY

Systematic Name

  • 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 10-((dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-, monohydrochloride, (S)-

Registry Numbers

CAS Registry Number

  • 119413-54-6

FDA UNII

  • 956S425ZCY

System Generated Number

  • 0119413546

Molecular Formulas

Molecular Formula

  • C23-H23-N3-O5.Cl-H

Molecular Formula Fragments

  • C23-H23-N3-O5
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C23H23N3O5.ClH/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20;/h5-8,27,30H,4,9-11H2,1-3H3;1H/t23-;/m0./s1

InChIKey

DGHHQBMTXTWTJV-BQAIUKQQSA-N

Smiles

CC[C@@]1(c2cc-3n(c(=O)c2COC1=O)Cc4c3nc5ccc(c(c5c4)CN(C)C)O)O.Cl