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Substance Name: Dabrafenib [USAN:INN]
RN: 1195765-45-7
UNII: QGP4HA4G1B
InChIKey: BFSMGDJOXZAERB-UHFFFAOYSA-N

Notes

  • An antineoplastic agent that inhibits BRAF kinase.
  • An antineoplastic agent that inhibits BRAF kinase.

    NCI: An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. (NCI Thesaurus)

Molecular Formula

  • C23-H20-F3-N5-O2-S2

Molecular Weight

  • 519.57
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Protein Kinase Inhibitors

Names and Synonyms

Name of Substance

  • Dabrafenib [USAN:INN]
  • GSK 2118436A

Synonyms

  • Dabrafenib
  • GSK 2118436
  • GSK2118436
  • GSK2118436A
  • Tafinlar
  • UNII-QGP4HA4G1B

Systematic Name

  • N-{3-(5-(2-aminopyrimidin-4-yl)-2-(1,1-dimethylethyl)thiazol-4-yl)-2-fluorophenyl}-2,6- difluorobenzenesulfonamide

Registry Numbers

CAS Registry Number

  • 1195765-45-7

FDA UNII

  • QGP4HA4G1B

System Generated Number

  • 1195765457

Structure Descriptors

InChI

1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)

InChIKey

BFSMGDJOXZAERB-UHFFFAOYSA-N

Smiles

CC(C)(C)c1nc(c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(s1)c4ccnc(N)n4