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Substance Name: Vinconate monohydrochloride
RN: 119600-43-0
UNII: H5MM0UO9N8
InChIKey: UVPBAANTIASPBO-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C18-H20-N2-O2.Cl-H

Molecular Weight

  • 332.829
 
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Names and Synonyms

Name of Substance

  • Vinconate monohydrochloride

Synonyms

  • OM 853
  • RTECS NU7448000
  • UNII-H5MM0UO9N8
  • Vinconate HCl
  • Vinconate hydrochloride

Systematic Name

  • 1H-Indolo(3,2,1-de)(1,5)naphthyridine-6-carboxylic acid, 2,3,3a,4-tetrahydro-3-ethyl-, methyl ester, monohydrochloride, (+-)-

Registry Numbers

CAS Registry Number

  • 119600-43-0

FDA UNII

  • H5MM0UO9N8

System Generated Number

  • 0119600430

Molecular Formulas

Molecular Formula

  • C18-H20-N2-O2.Cl-H

Molecular Formula Fragments

  • C18-H20-N2-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H20N2O2.ClH/c1-3-19-11-10-13-12-6-4-5-7-14(12)20-16(18(21)22-2)9-8-15(19)17(13)20;/h4-7,9,15H,3,8,10-11H2,1-2H3;1H

InChIKey

UVPBAANTIASPBO-UHFFFAOYSA-N

Smiles

C1[N@@]([C@@H]2CC=C(n3c2c(C1)c1ccccc31)C(=O)OC)CC.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 127mg/kg (127mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LIVER: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
mouse LD50 oral 699mg/kg (699mg/kg) LIVER: OTHER CHANGES

BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
mouse LD50 subcutaneous 3446mg/kg (3446mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat LD50 intravenous 112mg/kg (112mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LIVER: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat LD50 oral 2348mg/kg (2348mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat LD50 oral 2348mg/kg (2348mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat LD50 subcutaneous > 6gm/kg (6000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,