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Substance Name: Ici 206970
RN: 119646-52-5
InChIKey: BOOGSGUHOOWQBH-UHFFFAOYSA-N

Note

  • Has effects on Na+ & water excretion similar to hydrochlorothiazide.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C21-H31-Br-Cl-N7-O2

Molecular Weight

  • 528.88
 
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Names and Synonyms

Name of Substance

  • ICI 206970

Synonym

  • ICI 206970

Systematic Names

  • Pyrazinecarboxamide, 3,5-diamino-N-(2-((2-(((3-bromo-5-(1,1-dimethylethyl)-2-hydroxyphenyl)methyl)amino)ethyl)methylamino)ethyl)-6-chloro-
  • Pyrazinecarboxamide, N-(2-((2-(((3-bromo-5-(1,1-dimethylethyl)-2-hydroxyphenyl)methyl)amino)ethyl)methylamino)ethyl)-6-chloro-3,5-diamino-

Registry Numbers

CAS Registry Number

  • 119646-52-5

System Generated Number

  • 0119646525

Structure Descriptors

InChI

1S/C21H31BrClN7O2/c1-21(2,3)13-9-12(16(31)14(22)10-13)11-26-5-7-30(4)8-6-27-20(32)15-18(24)29-19(25)17(23)28-15/h9-10,26,31H,5-8,11H2,1-4H3,(H,27,32)(H4,24,25,29)

InChIKey

BOOGSGUHOOWQBH-UHFFFAOYSA-N

Smiles

c1(c(nc(c(n1)Cl)N)N)C(=O)NCC[N@@](C)CCNCc1c(c(cc(c1)C(C)(C)C)Br)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 300mg/kg (300mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Cardiovascular Drug Reviews. Vol. 12, Pg. 286, 1994.
mouse LD50 intraperitoneal > 100mg/kg (100mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Cardiovascular Drug Reviews. Vol. 12, Pg. 286, 1994.
mouse LD50 oral 1gm/kg (1000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Cardiovascular Drug Reviews. Vol. 12, Pg. 286, 1994.
rat LD50 intraperitoneal 100mg/kg (100mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Cardiovascular Drug Reviews. Vol. 12, Pg. 286, 1994.
rat LD50 oral > 1gm/kg (1000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Cardiovascular Drug Reviews. Vol. 12, Pg. 286, 1994.