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Substance Name: Tranexamic acid [USAN:USP:INN:BAN:JAN]
RN: 1197-18-8
UNII: 6T84R30KC1
InChIKey: GYDJEQRTZSCIOI-LJGSYFOKSA-N

Note

  • Antifibrinolytic hemostatic used in severe hemorrhage.

Molecular Formula

  • C8-H15-N-O2

Molecular Weight

  • 157.212
 

Classification Codes

  • Antifibrinolytic Agents
  • Coagulants
  • Drug / Therapeutic Agent
  • Fibrin Modulating Agents
  • Hematologic Agents
  • Hemostatic
  • Hemostatics
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Tranexamic acid
  • Tranexamic acid [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Tranexamic acid

Synonyms

  • 3-14-00-00868 (Beilstein Handbook Reference)
  • Acide tranexamique
  • Acide tranexamique [INN-French]
  • Acido tranexamico
  • Acido tranexamico [INN-Spanish]
  • Acidum tranexamicum
  • Acidum tranexamicum [INN-Latin]
  • Amikapron
  • Amstat
  • Anvitoff
  • BAY 3517
  • BRN 2207452
  • Carxamin
  • CL 65336
  • Cyclocapron
  • Cyklokapron
  • DV-79
  • EINECS 214-818-2
  • Emorhalt
  • Exacyl
  • Frenolyse
  • Hexapromin
  • Hexatron
  • Lysteda
  • Mastop
  • NSC 291305
  • Retavase
  • Rikavarin
  • Rikavarin-S
  • RP 18,429
  • Spiramin
  • Tamcha
  • Tranex
  • Tranexamic acid
  • Tranexamsaeure
  • Tranexan
  • Tranhexamic acid
  • trans Amcha
  • trans-1-Aminomethylcyclohexane-4-carboxylic acid
  • trans-4-(Aminomethyl)cyclohexanecarboxylic acid
  • trans-4-Aminomethylcyclohexane-1-carboxylic acid
  • trans-p-(Aminomethyl)cyclohexanecarboxylic acid
  • Transamin
  • Transamlon
  • Trasamlon
  • TXA
  • Ugurol
  • UNII-6T84R30KC1

Systematic Names

  • Cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-
  • Tranexamic acid

Registry Numbers

CAS Registry Number

  • 1197-18-8

FDA UNII

  • 6T84R30KC1

System Generated Number

  • 0001197188

Structure Descriptors

InChI

1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-

InChIKey

GYDJEQRTZSCIOI-LJGSYFOKSA-N

Smiles

C1[C@@H](CC[C@H](C1)CN)C(O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 oral > 10gm/kg (10000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 389, 1971.
dog LD50 intravenous 1110mg/kg (1110mg/kg)   Drugs in Japan Vol. 6, Pg. 512, 1982.
dog LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. 512, 1982.
mouse LD50 intraperitoneal 4200mg/kg (4200mg/kg)   "Modern Pharmaceuticals of Japan, V," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1975Vol. -, Pg. 108, 1975.
mouse LD50 intravenous 1350mg/kg (1350mg/kg)   Drugs in Japan Vol. 6, Pg. 512, 1982.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 512, 1982.
mouse LD50 subcutaneous 5310mg/kg (5310mg/kg)   Drugs in Japan Vol. 6, Pg. 512, 1982.
rat LD50 intravenous 1200mg/kg (1200mg/kg)   Acta Pharmacologica et Toxicologica. Vol. 22, Pg. 340, 1965.
rat LD50 subcutaneous 4620mg/kg (4620mg/kg)   Drugs in Japan Vol. 6, Pg. 512, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point >300 deg C   EXP
log P (octanol-water) -1.900 (none)   EST
Water Solubility 1.67E+05 mg/L   EXP
Atmospheric OH Rate Constant 4.37E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.