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Substance Name: Carzelesin [USAN:INN]
RN: 119813-10-4
UNII: 668UF07O1P
InChIKey: BBZDXMBRAFTCAA-AREMUKBSSA-N

Note

  • A cyclopropylpyrroloindole analog of U 73975; longer lasting than U 77779.

Classification Codes

  • Antineoplastic
  • Drug / Therapeutic Agent

Molecular Formula

  • C41-H37-Cl-N6-O5

Molecular Weight

  • 729.2333
 
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Names and Synonyms

Name of Substance

  • Carzelesin
  • Carzelesin [USAN:INN]

Synonyms

  • 2-Benzofurancarboxamide, N-(2-((1-(chloromethyl)-1,6-dihydro-8-methyl-5-(((phenylamino)carbonyl)oxy)benzo(1,2-b:4,3-b')dipyrrol-3(2H)-yl)carbonyl)-1H-indol-5-yl)-6-(diethylamino)-, (S)-
  • Carzelesin
  • N-(2-(((S)-1-(Chloromethyl)-1,6-dihydro-5-hydroxy-8-methylbenzo(1,2-b:4,3-b')dipyrrol-3(2H)-yl)carbonyl)indol-5-yl)-6-(diethylamino)-2-benzofurancarboxamide carbanilate (ester)
  • NSC 619029
  • NSC-619029
  • U 80244
  • U-80244
  • UNII-668UF07O1P

Systematic Names

  • 2-Benzofurancarboxamide, N-(2-((1-(chloromethyl)-1,6-dihydro-8-methyl-5-(((phenylamino)carbonyl)oxy)benzo(1,2-b:4,3-b')dipyrrol-3(2H)-yl)carbonyl)-1H-idnol-5-yl)-6-(diethylamino)-, (S)-
  • 2-Benzofurancarboxamide, N-(2-((1-(chloromethyl)-1,6-dihydro-8-methyl-5-(((phenylamino)carbonyl)oxy)benzo(1,2-b:4,3-b')dipyrrol-3(2H)-yl)carbonyl)-1H-indol-5-yl)-6-(diethylamino)-, (S)-

Registry Numbers

CAS Registry Number

  • 119813-10-4

FDA UNII

  • 668UF07O1P

System Generated Number

  • 0119813104

Structure Descriptors

InChI

1S/C41H37ClN6O5/c1-4-47(5-2)29-13-11-24-17-35(52-33(24)18-29)39(49)44-28-12-14-30-25(15-28)16-31(46-30)40(50)48-22-26(20-42)37-32(48)19-34(38-36(37)23(3)21-43-38)53-41(51)45-27-9-7-6-8-10-27/h6-19,21,26,43,46H,4-5,20,22H2,1-3H3,(H,44,49)(H,45,51)/t26-/m1/s1

InChIKey

BBZDXMBRAFTCAA-AREMUKBSSA-N

Smiles

CCN(CC)c1ccc2cc(oc2c1)C(=O)Nc3ccc4c(c3)cc([nH]4)C(=O)N5C[C@H](c6c5cc(c7c6c(c[nH]7)C)OC(=O)Nc8ccccc8)CCl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD10 intravenous 280ug/kg (0.28mg/kg)   Drugs of the Future. Vol. 21, Pg. 245, 1996.
rat LD10 intravenous 40ug/kg (0.04mg/kg)   Drugs of the Future. Vol. 21, Pg. 245, 1996.