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Substance Name: Dichlorphenamide [USP]
RN: 120-97-8
UNII: VVJ6673MHY
InChIKey: GJQPMPFPNINLKP-UHFFFAOYSA-N

Note

  • A carbonic anhydrase inhibitor that is used in the treatment of glaucoma.

Molecular Formula

  • C6-H6-Cl2-N2-O4-S2

Molecular Weight

  • 305.161
 

Classification Codes

  • Carbonic Anhydrase Inhibitor
  • Carbonic Anhydrase Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Dichlorphenamide
  • Dichlorphenamide [USP]
  • Diclofenamide [INN]

MeSH Heading

  • Dichlorphenamide

Synonyms

  • 1,3-Benzenedisulfonamide, 4,5-dichloro-
  • 1,3-Disulfamoyl-4,5-dichlorobenzene
  • 1,3-Disulfamyl-4,5-dichlorobenzene
  • 3,4-Dichloro-5-sulfamylbenzenesulfonamide
  • 4,5-Dichloro-1,3-disulfamoylbenzene
  • 4,5-Dichloro-m-benzenedisulfonamide
  • 4-11-00-00555 (Beilstein Handbook Reference)
  • Antidrasi
  • Barastonin
  • BRN 2703329
  • CB 8000
  • Daranide
  • Dichlofenamide
  • Dichlorophenamide
  • Dichlorphenamid
  • Dichlorphenamide
  • Diclofenamida
  • Diclofenamida [INN-Spanish]
  • Diclofenamide
  • Diclofenamidum
  • Diclofenamidum [INN-Latin]
  • EINECS 204-440-6
  • Fenamide
  • Glafco
  • Glajust
  • Glaucol
  • Glauconide
  • Glaumid
  • HSDB 3267
  • Keveyis
  • m-Benzenedisulfonamide, 4,5-dichloro-
  • Oratrol
  • UNII-VVJ6673MHY

Systematic Names

  • 1,3-Benzenedisulfonamide, 4,5-dichloro-
  • Diclofenamide
  • m-Benzenedisulfonamide, 4,5-dichloro-

Superlist Name

  • Dichlorphenamide

Registry Numbers

CAS Registry Number

  • 120-97-8

FDA UNII

  • VVJ6673MHY

System Generated Number

  • 0000120978

Structure Descriptors

InChI

1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14)

InChIKey

GJQPMPFPNINLKP-UHFFFAOYSA-N

Smiles

c1(cc(cc(c1Cl)Cl)S(N)(=O)=O)S(N)(=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 200mg/kg (200mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 41, 1969.
mouse LD50 intraperitoneal 304mg/kg (304mg/kg)   Therapie. Vol. 19, Pg. 1423, 1964.
mouse LD50 intravenous 643mg/kg (643mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 41, 1969.
mouse LD50 oral 1710mg/kg (1710mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 41, 1969.
rat LD50 intraperitoneal 1244mg/kg (1244mg/kg)   Drugs in Japan Vol. -, Pg. 446, 1990.
rat LD50 oral 10070mg/kg (10070mg/kg)   Drugs in Japan Vol. -, Pg. 446, 1990.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 228.7 deg C   EXP
log P (octanol-water) 1.060 (none)   EST
Atmospheric OH Rate Constant 1.83E-14 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.