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Substance Name: Pralidoxime methyl sulfate
RN: 1200-55-1
UNII: FQO9PAV523
InChIKey: OVPHBYQAKDEEBD-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C7-H9-N2-O.C-H3-O4-S

Molecular Weight

  • 248.2578
 
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Names and Synonyms

Name of Substance

  • Pralidoxime methyl sulfate

Synonyms

  • 2-Formyl-1-methylpyridinium methyl sulfate oxime
  • 7676 R. P.
  • Contrastigmin
  • Contrastigmine
  • EINECS 214-852-8
  • Methylsulphate de methyl-1 N-hydroxy-iminomethyl-2 pyridinium
  • Methylsulphate de methyl-1 N-hydroxy-iminomethyl-2 pyridinium [French]
  • NSC 164891
  • Pralidoxime methyl sulfate
  • Pyridine-2-aldoxime methylsulfate
  • RP 7676
  • Sulfomethylate de pralidoxime
  • Sulfomethylate de pralidoxime [French]
  • UNII-FQO9PAV523

Systematic Names

  • 2-((Hydroxyimino)methyl)-1-methylpyridinium methyl sulphate
  • Pyridinium, 2-((hydroxyimino)methyl)-1-methyl-, methyl sulfate (salt)
  • Pyridinium, 2-formyl-1-methyl-, methyl sulfate, oxime

Registry Numbers

CAS Registry Number

  • 1200-55-1

FDA UNII

  • FQO9PAV523

Other Registry Number

  • 37333-02-1

Related Registry Number

  • 6735-59-7 (Parent)

System Generated Number

  • 0001200551

Molecular Formulas

Molecular Formula

  • C7-H9-N2-O.C-H3-O4-S

Molecular Formula Fragments

  • C-H3-O4-S
  • C7-H9-N2-O
  • COMPONENT

Structure Descriptors

InChI

1S/C7H8N2O.CH4O4S/c1-9-5-3-2-4-7(9)6-8-10;1-5-6(2,3)4/h2-6H,1H3;1H3,(H,2,3,4)

InChIKey

OVPHBYQAKDEEBD-UHFFFAOYSA-N

Smiles

COS(=O)(=O)[O-].C[n+]1ccccc1\C=N\O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 145mg/kg (145mg/kg)   Medicina Experimentalis. Vol. 8, Pg. 313, 1963.
mouse LD50 intravenous 172mg/kg (172mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Therapie. Vol. 15, Pg. 1146, 1960.
mouse LD50 oral 1716mg/kg (1716mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Therapie. Vol. 15, Pg. 1146, 1960.
mouse LD50 subcutaneous 686mg/kg (686mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Therapie. Vol. 15, Pg. 1146, 1960.
rabbit LD50 intravenous 172mg/kg (172mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Therapie. Vol. 15, Pg. 1146, 1960.