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Substance Name: Donepezil [INN:BAN]
RN: 120014-06-4
UNII: 8SSC91326P
InChIKey: ADEBPBSSDYVVLD-UHFFFAOYSA-N

Note

  • FDA approved for the treatment of mild to moderate dementia of the Alzheimer type.

Molecular Formula

  • C24-H29-N-O3

Molecular Weight

  • 379.4971
 

Classification Codes

  • Central Nervous System Agents
  • Cholinergic Agents
  • Cholinesterase Inhibitors
  • Enzyme Inhibitors
  • Neurotransmitter Agents
  • Nootropic Agents

Names and Synonyms

Name of Substance

  • Donepezil
  • Donepezil [INN:BAN]

Synonyms

  • Donepezil
  • HSDB 7743
  • UNII-8SSC91326P

Systematic Name

  • 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-

Registry Numbers

CAS Registry Number

  • 120014-06-4

FDA UNII

  • 8SSC91326P

Related Registry Number

  • 120011-70-3

System Generated Number

  • 0120014064

Structure Descriptors

InChI

1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3

InChIKey

ADEBPBSSDYVVLD-UHFFFAOYSA-N

Smiles

N1(CCC(CC2C(=O)c3cc(c(cc3C2)OC)OC)CC1)Cc1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
women TDLo oral 1mg/kg (1mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: NAUSEA OR VOMITING

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE
Annals of Pharmacotherpy. Vol. 33, Pg. 812, 1999.