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Substance Name: Gadoteridol [USAN:USP:INN:BAN:JAN]
RN: 120066-54-8
UNII: 0199MV609F
InChIKey: DPNNNPAKRZOSMO-UHFFFAOYSA-K

Note

  • Nonionic magnetic resonance contrast agent.

Molecular Formula

  • C17-H29-Gd-N4-O7

Molecular Weight

  • 562.7187
 

Classification Codes

  • Contrast Media
  • Diagnostic Aid (Paramagnetic)
  • Diagnostic Uses of Chemicals
  • Drug / Therapeutic Agent

Names and Synonyms

Name of Substance

  • Gadoteridol
  • Gadoteridol [USAN:USP:INN:BAN:JAN]

Synonyms

  • (+-)-(10-(2-Hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-))gadolinium
  • (10-(2-Hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato)gadolinium
  • Gadolinium, (10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-)-N(sup 1),N(sup 4),N(sup 7),N(sup 10),O(sup 1),O(sup 4),O(sup 7),O(sup 10))-
  • Gadolinium-HP-Do 3A
  • Gadolinium-HP-DO3A
  • Gadoteridol
  • Gadoteridolum
  • Gadoteridolum [INN-Latin]
  • GD-HP-DO 3A
  • HSDB 7549
  • ProHance
  • Prohance multipack
  • SQ 32,692
  • SQ 32692
  • UNII-0199MV609F

Systematic Names

  • 1,4,7,10-Tetraazacyclododecan-1,4,7-triacetic acid, 10-(2-hydroxypropyl)-, gadolinium complex
  • Gadolinium, (10-(2-(hydroxy-kappaO)propyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-)-kappaN1,kappaN4,kappaN7,kappaN10,kappaO1,kappaO4,kappaO7)-
  • Gadolinium, (10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-)-N(sup 1),N(sup 4),N(sup 7),N(sup 10),O(sup 1),O(sup 4),O(sup 7),O(sup 10))-

Registry Numbers

CAS Registry Number

  • 120066-54-8

FDA UNII

  • 0199MV609F

Other Registry Number

  • 909570-46-3

System Generated Number

  • 0120066548

Structure Descriptors

InChI

1S/C17H32N4O7.Gd/c1-14(22)10-18-2-4-19(11-15(23)24)6-8-21(13-17(27)28)9-7-20(5-3-18)12-16(25)26;/h14,22H,2-13H2,1H3,(H,23,24)(H,25,26)(H,27,28);/q;+3/p-3

InChIKey

DPNNNPAKRZOSMO-UHFFFAOYSA-K

Smiles

[N]123CC[N]45CC[N]67CC[N]8(CC1)CC(=O)[O-][Gd+3]3578([OH]C(C2)C)([O-]C(=O)C4)[O-]C(=O)C6

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous > 2800mg/kg (2800mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 1409, 1994.
mouse LD50 intravenous 6146mg/kg (6146mg/kg)   Drugs of the Future. Vol. 17, Pg. 187, 1992.
rat LD intravenous > 5587mg/kg (5587mg/kg)   Drugs of the Future. Vol. 17, Pg. 187, 1992.