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Substance Name: Unoprostone isopropyl
RN: 120373-24-2
UNII: 5M161S5O5P
InChIKey: XXUPXHKCPIKWLR-JHUOEJJVSA-N

Note

  • A safe and effective ocular hypotensive drug.

Classification Codes

  • Antihypertensive Agents
  • Cardiovascular Agents

Molecular Formula

  • C25-H44-O5

Molecular Weight

  • 424.6176
 
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Names and Synonyms

Results Name

  • Unoprostone isopropyl

Name of Substance

  • Isopropyl unoprostone

Synonyms

  • 13,14-Dihydro-15-keto-20-ethyl-PGF2
  • Isopropyl unoprostone
  • Rescula
  • UF 021
  • UF-021
  • UNII-5M161S5O5P
  • Unoprostone isopropyl ester

Systematic Name

  • 5-Heptenoic acid, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl)-, 1-methylethyl ester, (5Z)-

Registry Numbers

CAS Registry Number

  • 120373-24-2

FDA UNII

  • 5M161S5O5P

Other Registry Number

  • 1044661-14-4

System Generated Number

  • 0120373242

Structure Descriptors

InChI

1S/C25H44O5/c1-4-5-6-7-10-13-20(26)16-17-22-21(23(27)18-24(22)28)14-11-8-9-12-15-25(29)30-19(2)3/h8,11,19,21-24,27-28H,4-7,9-10,12-18H2,1-3H3/b11-8-/t21-,22-,23+,24-/m1/s1

InChIKey

XXUPXHKCPIKWLR-JHUOEJJVSA-N

Smiles

CCCCCCCC(=O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(=O)OC(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD intravenous > 40mg/kg (40mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 3348, 1994.
rat LD50 intravenous 93500ug/kg (93.5mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BLOOD: HEMORRHAGE
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 3348, 1994.
rat LD50 subcutaneous 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BLOOD: HEMORRHAGE
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 3348, 1994.