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Substance Name: Epacadostat [USAN]
RN: 1204669-58-8
UNII: 71596A9R13
InChIKey: FBKMWOJEPMPVTQ-UHFFFAOYSA-N

Note

  • NCI: An orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase (IDO1), with potential immunomodulating and antineoplastic activities. epacadostat targets and binds to IDO1, an enzyme responsible for the oxidation of tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, epacadostat increases and restores the proliferation and activation of various immune cells, including dendritic cells (DCs), NK cells, and T-lymphocytes, as well as interferon (IFN) production, and a reduction in tumor-associated regulatory T cells (Tregs). Activation of the immune system, which is suppressed in many cancers, may inhibit the growth of IDO1-expressing tumor cells. IDO1 is overexpressed by a variety of tumor cell types and DCs. (NCI Thesaurus)

Molecular Formula

  • C11-H13-Br-F-N7-O4-S

Molecular Weight

  • 438.2367
 

Classification Code

  • Treatment of Cancer
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Names and Synonyms

Name of Substance

  • Epacadostat [USAN]

Synonyms

  • (Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-(2- (sulfamoylamino)ethylamino)-1,2,5-oxadiazole-3-carboxamidine
  • Epacadostat
  • INCB 024360
  • INCB024360
  • UNII-71596A9R13

Systematic Name

  • 1,2,5-Oxadiazole-3-carboximidamide, 4-((2-((aminosulfonyl)amino)ethyl)amino)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-, (C(Z))-

Registry Numbers

CAS Registry Number

  • 1204669-58-8

FDA UNII

  • 71596A9R13

System Generated Number

  • 1204669588

Structure Descriptors

InChI

1S/C11H13BrFN7O4S/c12-7-5-6(1-2-8(7)13)17-11(18-21)9-10(20-24-19-9)15-3-4-16-25(14,22)23/h1-2,5,16,21H,3-4H2,(H,15,20)(H,17,18)(H2,14,22,23)

InChIKey

FBKMWOJEPMPVTQ-UHFFFAOYSA-N

Smiles

NS(=O)(=O)NCCNc1nonc1\C(=N\O)\Nc2ccc(F)c(Br)c2