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Substance Name: Anastrozole [USAN:USP:INN:BAN]
RN: 120511-73-1
UNII: 2Z07MYW1AZ
InChIKey: YBBLVLTVTVSKRW-UHFFFAOYSA-N
Notes
- A nitrile and triazole derivative that acts as a selective nonsteroidal aromatase inhibitor. It is used in the treatment of ESTROGEN NUCLEAR RECEPTOR-positive breast cancer in postmenopausal women.
- Aromatase inhibitor.
NCI: A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure. As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, anastrozole may inhibit tumor growth. (NCI Thesaurus)
Molecular Formula
- C17-H19-N5
Molecular Weight
- 293.3721
Classification Codes
- Antineoplastic
- Antineoplastic Agents
- Antineoplastic Agents, Hormonal
- Aromatase Inhibitors
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Estrogen Antagonists
- Hormone Antagonists
- Steroid Synthesis Inhibitors
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Names and Synonyms
Name of Substance
- Anastrozole
- Anastrozole [USAN:USP:INN:BAN]
MeSH Heading
- Anastrozole
Synonyms
- alpha,alpha,alpha',alpha'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile
- Anastrazole
- Anastrozole
- Arimidex
- Asiolex
- CCRIS 9352
- HSDB 7462
- ICI D1033
- ICI-D 1033
- NSC 719344
- NSC 759855
- UNII-2Z07MYW1AZ
- ZD 1033
- ZD-1033
- ZD1033
Systematic Name
- 1,3-Benzenediacetonitrile, alpha,alpha,alpha',alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-
Registry Numbers
CAS Registry Number
- 120511-73-1
FDA UNII
- 2Z07MYW1AZ
System Generated Number
- 0120511731