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Substance Name: Anastrozole [USAN:USP:INN:BAN]
RN: 120511-73-1
UNII: 2Z07MYW1AZ
InChIKey: YBBLVLTVTVSKRW-UHFFFAOYSA-N

Notes

  • Aromatase inhibitor.
  • Aromatase inhibitor.

    NCI: A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure. As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, anastrozole may inhibit tumor growth. (NCI Thesaurus)

Molecular Formula

  • C17-H19-N5

Molecular Weight

  • 293.3721
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
  • Antineoplastic Agents, Hormonal
  • Aromatase Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Estrogen Antagonists
  • Hormone Antagonists
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Steroid Synthesis Inhibitors

Names and Synonyms

Name of Substance

  • Anastrozole
  • Anastrozole [USAN:USP:INN:BAN]

Synonyms

  • alpha,alpha,alpha',alpha'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile
  • Anastrazole
  • Anastrozole
  • Arimidex
  • Asiolex
  • CCRIS 9352
  • HSDB 7462
  • ICI D1033
  • ICI-D 1033
  • UNII-2Z07MYW1AZ
  • ZD 1033
  • ZD-1033
  • ZD1033

Systematic Name

  • 1,3-Benzenediacetonitrile, alpha,alpha,alpha',alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-

Registry Numbers

CAS Registry Number

  • 120511-73-1

FDA UNII

  • 2Z07MYW1AZ

System Generated Number

  • 0120511731

Structure Descriptors

InChI

1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3

InChIKey

YBBLVLTVTVSKRW-UHFFFAOYSA-N

Smiles

CC(C)(C#N)c1cc(cc(c1)C(C)(C)C#N)Cn2cncn2