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Substance Name: BMN-673 (Racemic)
RN: 1207454-56-5
InChIKey: HWGQMRYQVZSGDQ-UHFFFAOYSA-N

Note

  • NCI: An orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP inhibitor BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. (NCI Thesaurus)

Molecular Formula

  • C19-H14-F2-N6-O

Molecular Weight

  • 380.3566
 
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Names and Synonyms

Results Name

  • BMN-673 (Racemic)

Name of Substance

  • BMN-673

Synonyms

  • BMN 673
  • BMN673

Registry Numbers

CAS Registry Number

  • 1207454-56-5

System Generated Number

  • 1207454565

Structure Descriptors

InChI

1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,24H,1H3,(H,26,28)

InChIKey

HWGQMRYQVZSGDQ-UHFFFAOYSA-N

Smiles

Cn1c(ncn1)C2c3c4c(cc(cc4NC2c5ccc(cc5)F)F)c(=O)[nH]n3